Behavior of the immunoglobulines in the follow-up of patients with multiple mieloma. University Hospital “Comandante Faustino Pérez”. Matanzas

Abstract

Introduction: monoclonal gammopathies are a group of disorders characterized for the proliferation of a clone of plasmatic cells that synthesize a monoclonal immunoglobulin; among them, an example of plasmatic cells neoplasias is the multiple myeloma, an entity characterized by the abnormal production of immunoglobulins.

Objective: to describe the behavior of immunoglobulins in the follow-up of patients with multiple myeloma in the Hematology Service of the University Hospital “Comandante Faustino Pérez”, of Matanzas.

Materials and methods: longitudinal-prospective-descriptive study. The universe of study was open and the sample was all the patients with debuting multiple myeloma, during the period from June 1^st 2013 to May 31^st 2014, to whom the determination of IgA, IgG and IgM immunoglobulins was carried out.

Results: the diminished values of IgA and IgG showed a very good answer to the treatment after six and 12 months. At the sixth months of the treatment the IgM was modified to augmented values classifying as refractory; this behavior relapsed at the twelfth month, reaching 13 % more than before the treatment.

Conclusions: the markers of better answer to the treatment were the IgA and IgG immunoglobulins