Neurosurgical advances and molecular biology in the treatment of glioblastoma multiforme
Keywords:
glioblastoma multiple, molecular biology, surgical resection.Abstract
Despite advances in radiotherapy, chemotherapy and aggressive surgical resection treatments in glioblastoma multiforme, the prognosis remains discouraging. With the current review, the main alternatives for the treatment of glioblastoma multiforme are described in a current context. The authors reviewed the main articles published in English, in high impact journals worldwide, on the main advances in the treatment of this tumor. The main neurosurgical advances in the resection of glioblastoma were addressed, as well as the implications of tumor stem cells in the genesis and control of tumor proliferation, as well as the effect of hypoxia on tumor cell dynamics. DNA alterations causing tumor genesis and PTEN mutations in glioblastoma are also explainedDownloads
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26. Pengcheng Li, Chun Zhou, Lunshan Xu, Hualiang Xiao. Hypoxia Enhances Stemness of Cancer Stem Cells in Glioblastoma: An In Vitro Study. Int. J. Med. Sci. 2013, Vol. 10. 2013; 10(4):399-407. doi: 10.7150/ijms.5407
2. Lara-Velazquez M., et al. Advances in Brain Tumor Surgery for Glioblastoma in Adults. Brain Sci. 2017, 7, 166; doi:10.3390/brainsci7120166
3. Gronych J, Pfister E, Jones D. Connect Four with Glioblastoma Stem Cell Factors. Cell 157, April 24, 2014 Elsevier Inc.
4. Pengcheng Li, Chun Zhou, Lunshan Xu, Hualiang Xiao. Hypoxia Enhances Stemness of Cancer Stem Cells in Glioblastoma: An In Vitro Study. Int. J. Med. Sci. 2013, Vol. 10. 2013; 10(4):399-407. doi: 10.7150/ijms.5407
5. Gómez-Vega JC., Ocampo Navia MI., Feo Lee O. Epidemiología y caracterización general de los tumores cerebrales primarios en el adulto. Univ Med. 2019; 60 (1). doi: http://dx.doi.org/10.11144/Javeriana.umed60-1.cere
6. WILEY J & SONS. Cirugía guiada por imágenes para la resección de tumores cerebrales (Revision Cochrane traducida). Cochrane Database of Systematic Reviews 2014 Issue 1. Art. No.: CD009685. DOI: 10.1002/14651858.CD009685.
7. Valenzuela R. Nuevas terapias en el manejo de los gliomas de alto grado. [REV. MED. CLIN. CONDES - 2017; 28(3) 401-408]
8. Kut, C.; Chaichana, K.L.; Xi, J.; Raza, S.M.; Ye, X.; McVeigh, E.R.; Rodriguez, F.J.; Quinones-Hinojosa, A.; Li, X. Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography. Sci. Transl. Med. 2015, 7. [CrossRef] [PubMed]
9. Iftimia, N.; Hammer, D.X.; Mujat, M.; Desphande, V.; Cizginer, S.; Brugge, W. Optical coherence tomography imaging for cancer diagnosis and therapy guidance. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2009, 4067–4069. [PubMed]
10. Sardi Correa C, Acosta Cadavid C, Rodríguez Gómez AM, Mejía Estrada ME, Vásquez Trespalacios EM. Grosor coroideo central en sujetos hispanos sanos medido por tomografía de coherencia óptica con imagen de profundidad mejorada. Rev Mex Oftalmol. 2017;91(1):2---8
11. Moore, G.E.; Peyton, W.T.; French, L.A.; Walker, W.W. The clinical use of fluorescein in neurosurgery; the localization of brain tumors. J. Neurosurg. 1948, 5, 392–398. [CrossRef] [PubMed]
12. Vidal-Sicart S, Valdés Olmos R, Nieweg O E et al. De la imagen intervencionista a la guía intraoperatoria: nuevas perspectivas combinando herramientas avanzadas y navegación con la cirugía radioguiada. Rev Esp Med Nucl Imagen Mol. 2018;37(1):28–40. https://doi.org/10.1016/j.remn.2017.06.004
13. Díez Valle R, Slof J, Galván J, Arza A et al. Estudio observacional retrospectivo sobre la efectividad del ácido5-aminolevulínico en la cirugía de los gliomas malignos en España (Estudio VISIONA). Neurología. 2014; 29(3):131—138. doi:10.1016/j.nrl.2013.05.004
14. Slof J, Díez Valle R, Galván J. Análisis coste-efectividad de la cirugía del glioma maligno guiada por fluorescencia con ácido 5-aminolevulínico. Neurología. 2015;30:163—168. http://dx.doi.org/10.1016/j.nrl.2013.11.002
15. Castle M, Nájera E, Samprón N. et al. Biopsia cerebral estereotáctica sin marco: capacidad diagnóstica y complicaciones. Neurocirugía. 2014; 2 5(2):56–61. http://dx.doi.org/10.1016/j.neucir.2013.11.003
16. Eseonu, C.I.; Rincon-Torroella, J.; ReFaey, K.; Lee, Y.M.; Nangiana, J.; Vivas-Buitrago, T.; Quinones-Hinojosa, A. Awake craniotomy vs. craniotomy under general anesthesia for perirolandic gliomas: Evaluating perioperative complications and extent of resection. Neurosurgery 2017, 81, 481–489. [CrossRef] [PubMed]
17. Lau, D.; Hervey-Jumper, S.L.; Han, S.J.; Berger, M.S. Intraoperative perception and estimates on extent of resection during awake glioma surgery: Overcoming the learning curve. J. Neurosurg. 2017, 1–9. [CrossRef] [PubMed]
18. Schwarzmaier, H.J.; Eickmeyer, F.; von Tempelhoff, W.; Fiedler, V.U.; Niehoff, H.; Ulrich, S.D.; Yang, Q.; Ulrich, F. Mr-guided laser-induced interstitial thermotherapy of recurrent glioblastoma multiforme: Preliminary results in 16 patients. Eur. J. Radiol. 2006, 59, 208–215. [CrossRef] [PubMed]
19. Martirosyan, N.L.; Cavalcanti, D.D.; Eschbacher, J.M.; Delaney, P.M.; Scheck, A.C.; Abdelwahab, M.G.; Nakaji, P.; Spetzler, R.F.; Preul, M.C. Use of in vivo near-infrared laser confocal endomicroscopy with indocyanine green to detect the boundary of infiltrative tumor. J. Neurosurg. 2011, 115, 1131–1138. [CrossRef] [PubMed]
20. Pirro, V.; Alfaro, C.M.; Jarmusch, A.K.; Hattab, E.M.; Cohen-Gadol, A.A.; Cooks, R.G. Intraoperative assessment of tumor margins during glioma resection by desorption electrospray ionization-mass spectrometry. Proc. Natl. Acad. Sci. USA 2017, 114, 6700–6705. [CrossRef] [PubMed]
21. Ping Huang., et al. CBIO-20. GLIOBLASTOMA SPECIFIC PROTEINS IDENTIFIED THROUGH COMBINED IN VITRO AND IN VIVO PHAGE DISPLAY BIOPANNING. Neuro-Oncology 17:v55–v65, 2015. doi:10.1093/neuonc/nov209.20
22. Sonikpreet Aulakh., et al. CD38-targeted therapy in glioblastoma: A step forward. DOI: 10.1200/JCO.2018.36.15_suppl.e14030 Journal of Clinical Oncology - published online before print June 1, 2018
23. Yang Jr-M., et al. Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization. Oncogene (2017) 36, 3673–3685. www.nature.com/onc
24. Erasimus E, Gobin M, Niclou S, Van Dyck E. DNA repair mechanisms and their clinical impact in glioblastoma. Mutation Research 769 (2016) 19–35. Journal homepage: www.elsevier.com/locate/reviewsmr Communit y address: www.elsevier.com/locat e/mutres
25. Kristoffersen K, Stockhausen M, Poulsen H. Department of Radiation Biology, National University Hospital. NOTCH PATHWAY BLOCKADE AFFECTS THE DIFFERENTIATING AND MIGRATORY CAPACITY OF BRAIN TUMOR INITIATING CELLS. NEURO-ONCOLOGY-NOVEMBER 2010
26. Pengcheng Li, Chun Zhou, Lunshan Xu, Hualiang Xiao. Hypoxia Enhances Stemness of Cancer Stem Cells in Glioblastoma: An In Vitro Study. Int. J. Med. Sci. 2013, Vol. 10. 2013; 10(4):399-407. doi: 10.7150/ijms.5407
Published
2019-10-03
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1.
Sierra Benitez EM, León Pérez M, Morales Fuentes MA. Neurosurgical advances and molecular biology in the treatment of glioblastoma multiforme. Rev Méd Electrón [Internet]. 2019 Oct. 3 [cited 2025 Feb. 2];41(5):1259-68. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/3193
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