Prevalence of single umbilical artery in pregnant women: its relationship with other malformations and low birth weight

Authors

Keywords:

single umbilical artery, two vessels of the cord, malformation, low birth weight

Abstract

Introduction: The single umbilical artery has an incidence of 1% in newborns. It is frequently associated with twinning, malformations and delayed intrauterine growth, and is a risk factor of prematurity, fetal and neonatal death.

Objective: To determine the prevalence of single umbilical artery in pregnant women and the association of this entity with other malformations and low birth weight.

Materials and methods: Retrospective descriptive study, with data obtained from medical records and the linear follow-up model existing in the community genetic clinics of the municipality of Matanzas, from January 2015 to December 2019.

Results: The prevalence of the single umbilical artery was 0.3%. The most frequent malformations were renal ones; 27.7% of births were pre-term and 33.3% of those born weighed less than 2500g.

Conclusions: The single umbilical artery is a marker for other malformations. When both coexist there is a risk of prematurity and low birth weight. Postnatal clinical examination is recommended for all newborns with single umbilical artery, checking for renal and heart defects.

Downloads

Download data is not yet available.

References

1. Malova J, Bohmer D, Luha J, et al. Single umbilical and reproductions losses in Slovak populations: relation to karyotype and fetal anomalies. Bratisl Med J. 2018;119(6):330-4. DOI: 10.4149/bll_2018_062.

2. Li TG, Nie F, Li ZD, et al. Evaluation of right ventricular function in fetuses with isolate single umbilical artery using spatiotemporal image correlation M-mode. Cardiovasc Ultrasound. 2019;17(1):14. DOI: 10.1186/s12947-019-0164-0.

3. Viñet Espinosa LM, Correa Branco LS. Retardo en la caída del cordón umbilical por persistencia del conducto onfalomesentérico. Presentación de caso. Panorama Cuba y Salud [Internet]. 2017 [citado 11/01/2022];12(2):45-8. Disponible en: https://www.redalyc.org/articulo.oa?id=477355402008

4. García-Rabasco AE, Subiabre-Ferrer D, Alegre-de-Miquel V. Patología del área umbilical. Medicina Clínica Práctica [Internet]. 2019 [citado 11/01/2022];2(6):105-8. Disponible en: https://doi.org/10.1016/j.mcpsp.2019.08.002

5. Medina-Gaona LA, Neira-Maguey E. Recién nacido sano con arteria umbilical única y nudo verdadero en el cordón umbilical. Rev Mex Pediatr [Internet]. 2022 [citado 16/10/2023];89(4):158-61. Disponible en: https://doi.org/10.35366/109591

6. Blum M, Weintraub AY, Baumfeld Y, et al. Perinatal outcomes of small for gestational age neonates born whit an isolated single umbilical artery. Front Pediatr. 2019;7:79. DOI: 10.3389/fped.2019.00079.

7. Kim HJ, Kim JH, Chay DB, et al. Association of isolate single umbilical artery with perinatal outcomes: systematic review and meta-analysis. Obstet Gynecol Sci. 2017;60(3):266-73. DOI: 10.5468/ogs.2017.60.3.266.

8. Abdelazim IA, Abu-Faza M, Hamed MES, et al. Prenatal diagnosis of single umbilical artery complicated by intrauterine growth retardation and preterm labor: Case report. J family Med Prim Care. 2019;8(6):2151-4. DOI: 10.4103/jfmpc.jfmpc_394_19.

9. Ebbing C, Kessler J, Moster D, et al. Isolate single umbilical artery and the risk of adverse perinatal outcome and third stage of labor complications: A population-based study. Acta Obstet Gynecol Scand. 2020;99(3):374-80. Disponible en: https://doi.org/10.1111/aogs.13747

10. Rittler M, Mazzitelli N, Fuksman R, et al. Arteria umbilical única y malformaciones asociadas en una serie de 5.500 autopsias. Implicancia en conductas perinatales. Pediatr Dev Pathol. 2010;13(6):465-70. DOI: 10.2350/10-01-0788-OA.

11. Nazer HJ, Jarpa C, Cifuentes OL. Incidencia y asociaciones de Arteria umbilical única en recién nacidos: Maternidad del hospital clínico de la Universidad de Chile, 1998-2010. Rev Chil Obstet Ginecol [Internet]. 2011 [citado 11/01/2022];76(1):21-5. Disponible en: https://www.scielo.cl/scielo.php?pid=S0717-75262011000100005&script=sci_abstract

12. Almanza Más M, Blanco M, García D, et al. Arteria Umbilical Única: Incidencias y relaciones con otras anomalías. Rev Cub Pediatr. 1988;60(4):473-81.

13. Akinmoladun JA, Bello OO. Prevalence of prenatal ultrasound diagnosed single umbilical artery in a cohort with associated congenital malformations. Trop J Obstet Gynaecol [Internet]. 2018 [citado 05/03/2021];35(3):304-9. Disponible en: https://www.tjogonline.com/article.asp?issn=0189-5117;year=2018;volume=35;issue=3;spage=304;epage=309;aulast=Akinmoladun

14. Martínez-Payo C, Cabezas E, Nieto Y, et al. Detection of Single Umbilical Artery in the First Trimester Ultrasound: Its Value as a Marker of Fetal Malformation. Biomed Res Int [Internet]. 2014 [citado 08/01/2021];2014:548729. Disponible en: https://dx.doi.org/10.1155/2014/548729

15. Friebe-Hoffmann U, Hiltmann A, Friedl TWP, et al. Prenatally Diagnosed Single Umbilical Artery (SUA) - Retrospective Analysis of 1169 Fetuses. Ultraschall Med. 2019;40(2):221-9. DOI: 10 1055/s-0043-123463.

16. Ebbing C, Kessler J, Moster D, et al. Single umbilical artery and risk of congenital malformation: population-based study in Norway. Ultrasound Obstet Gynecol. 2020;55(4):510-5. DOI: 10.1002/uog.20359.

17. Huamán GM, Quiroga de Michelena MI, Martin B, et al. Diagnóstico prenatal de anomalías cromosómicas. Biopsia de vellosidades coriales y amniocentesis para cariotipo fetal. Rev Peru Ginecol Obstet [Internet]. 2016 [citado 05/03/2021];62(3):269-77. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S2304-51322016000300009

18. Naviero-Fuentes M, Carrillo-Badillo MP, Molde-Conde J, et al. Perinatal outcome in singleton pregnancies with a single umbilical artery. J Matern Fetal Neonatal Med. 2016;29(10):1562-5. DOI: 10.3109/14767058.2015.1053864.

19. Sakar MN, Oğlak SC, Saridas Demir S, et al. Isolated single umbilical artery. East J Med. 2020;25(3):444-9. DOI: 10.5505/ejm.2020.13540.

20. Luo X, Zhai S, Shi N, et al. The risk factors and neonatal outcomes of isolated single umbilical artery in singlenton pregnancy: A meta-analysis. Sci Rep [Internet]. 2017 [citado 09/01/2021];7(1):7396. Disponible en: https://doi.org/10.1038/s41598-017-07053-7

21. Caldas LM, Liao A, Carvalho MH, et al. Should fetal growth be a matter of concern in isolated single umbilical artery? Rev Assoc Med Bras [Internet]. 2014 [citado 04/03/2021];60(2):125-30. Disponible en: https://doi.org/10.1590/1806-9282.60.02.009

Published

2023-11-08

How to Cite

1.
Horta-Barrios AB, Rodriguez-Quintana M, Revuelta-Trujillo R, Alfonso-Acosta AE, Luna-Ceballos EJ. Prevalence of single umbilical artery in pregnant women: its relationship with other malformations and low birth weight. Rev Méd Electrón [Internet]. 2023 Nov. 8 [cited 2025 Jan. 10];45(6):e4882. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/4882

Issue

Section

Research article

Most read articles by the same author(s)