Efficacy of BiolineTM Malaria Ag P.f/P.v test for early diagnosis of malaria in Angolan children
Keywords:
plasmodium, malaria, diagnosis, effectiveness, AngolaAbstract
Introduction: Malaria is an infectious disease caused by parasites of the genus Plasmodium, and affects all regions of the African continent. In Angola, it is responsible for 35% of mortality in children under five years of age. In Huambo, in 2021, there was an increase in the number of cases above the national average, reporting an incidence rate of 384 cases per 1000 inhabitants, and in the Ecunha municipality figures of 71,089 cases, a rate of 680 cases per every 1000. The thick smear is the method of choice for the diagnosis of malarial infection. Different researchers describe the BiolineTM Malaria Ag P.f/P.v rapid diagnostic strips as a suitable method for the diagnosis of malaria infection. In the Ecunha municipality, there are difficulties in performing thick smears on all patients, so the use of rapid diagnostic strip techniques could offer a good alternative for early diagnosis and immediate treatment of infected children.
Objective: to determine the effectiveness of the BiolineTM Malaria Ag P.f/P.v rapid diagnostic test, for the early diagnosis of malaria in children, in the Ecunha municipality, Huambo province, Angola.
Methods: An evaluation of the diagnostic method of malaria infection was carried out at the Municipal Hospital of Ecunha, Huambo, Angola, between April 2021 and April 2022.
Results: Although malaria constitutes one of the metaxenic diseases at the national level, few figures are available regarding the usefulness of rapid tests in the Angolan population, including asymptomatic patients or those with low parasitemia, compared to thick and extended smear.
Conclusions: The BiolineTM Malaria Ag P.f/P.v rapid diagnostic test presented a similar efficacy for the diagnosis of malaria infection compared to the thick smear.plasmodium; malaria; diagnosis; effectiveness; Angola
Downloads
References
2. Reis H, Franco J, Dimbu PR, et al. Manual de Diagnóstico e Tratamento da Malária. 4ª ed. Luanda: Ministério de Saúde; 2021.
3. Tan AF, Sakam SS, Rajahram GS, et al. Diagnostic accuracy and limit of detection of ten malaria parasite lactate dehydrogenase-based rapid tests for Plasmodium knowlesi and P. falciparum. Front Cell Infect Microbiol. 2022;12. DOI: 10.3389/fcimb.2022.1023219.
4. World Health Organization. World Malaria Report 2020 [Internet]. Geneva: WHO; 2020 [citado 13/11/2022]. Disponible en: https://www.who.int/publications/i/item/9789240015791
5. Agarwal R, Choi L, Johnson S, et al. Rapid diagnostic tests for Plasmodium vivax malaria in endemic countries. Cochrane Libr. 2020;11:CD013218. DOI: 10.1002/14651858.CD013218.pub2.
6. Ministerio de Salud de Chile. Informe: Situación epidemiológica, diagnóstico y tratamiento de Malaria [Internet]. Santiago de Chile: Ministerio de Salud de Chile; 2020 [citado 13/11/2022]. Disponible en: https://diprece.minsal.cl/wp-content/uploads/2021/02/Informe-Situacion-epidemiologica-diagnostico-y-tratamiento-de-malaria-2020.pdf
7. García NP, Da Silva F, Fortes F, et al. Comparación de los métodos de gota gruesa y tiras de diagnóstico rápido para el diagnóstico de la malaria en Luanda, Angola. Rev haban cienc méd [Internet]. 2015 [citado 13/11/2022];14(1). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1729-519X2015000100015
8. Jercic Lara MI. Parasitosis en migrantes: Actualización. Parasitol latinoam [Internet]. 2021 [citado 13/11/2022];70(1):53-4. Disponible en: https://sociedadchilenaparasitologia.cl/wp-content/uploads/2019/10/Revista-Parasitolog%C3%ADa-Latinoamericana-2021-Vol-70-N1-ok.pdf
9. West K, González Juárez R, Nanclares C. El tratamiento de la malaria en el entorno COVID-19. RIECS. 2021;6(S1):55-62. DOI: 10.37536/RIECS.2021.6.S1.250.
10. Martín Ramírez S, Muñoz Garcia C, Lanza M, et al. Diagnóstico de malaria en un centro de referencia: Pasado, presente y futuro. RIECS. 2021;6(S1):43-51. DOI: 10.37536/RIECS.2021.6.S1.245.
11. Arróspide N, Sanabria H, Araujo-Banchon WJ. Evaluación de la efectividad de la prueba rápida OptiMAL-IT™ para el seguimiento de pacientes con diagnóstico de malaria en la Amazonía peruana. Biomédica. 2022;42(1):147-58. DOI: 10.7705/biomedica.6079.
12. Ansah EK, Epokor M, Whitty CJ, et al. Cost-effectiveness analysis of introducing RDTs for malaria diagnosis as compared to microscopy and presumptive diagnosis in central and peripheral public health facilities in Ghana. Am J Trop Med Hyg [Internet]. 2013 [citado 13/11/2022];89(4):724-36. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795104/
13. Umpiérrez María I, Notejane M, Zabala C, et al. Malaria importada en niños: primer caso en Uruguay. Arch Pediatr Urug. 2021;92(1):e302. DOI: 10.31134/AP.92.1.7.
14. Jazmín Cortés L, Patricia Guerra A. Análisis de concordancia de tres pruebas para el diagnóstico de malaria en población sintomática de municipios endémicos de Colombia. Biomédica. 2020;40(1). DOI: 10.7705/biomedica.4893.
15. Fançony C, Sebastião YV, Pires JE, et al. Performance of microscopy and RDTs in the context of a malaria prevalence survey in Angola: a comparison using PCR as the gold standard. Malar J [Internet]. 2013 [citado 13/11/2022];12(284). Disponible en: https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-12-284
16. Espinoza J. Enfermedades infecciosas desatendidas y olvidadas en Latinoamérica y su importancia para Chile. Bol Micol. 2023;38(1). DOI: 10.22370/bolmicol.2023.38.1.3804.
17. Okumu F, Finda M. Key characteristics of residual malaria transmission in two districts in south-eastern Tanzania-implications for improved control. J Infect Dis [Internet]. 2021 [citado 13/11/2022];223(Suppl 2):S143-54. Disponible en: https://academic.oup.com/jid/article/223/Supplement_2/S143/6255898
18. Berzosa P, de Lucio A, Romay-Barja M, et al. Comparison of three diagnostic methods (microscopy, RDT, and PCR) for the detection of malaria parasites in representative samples from Equatorial Guinea. Malar J. 2018;17(1):333. DOI: 10.1186/s12936-018-2481-4.
19. Berhane A, Russom M, Bahta I, et al. Rapid diagnostic tests to detect Plasmodium falciparum infections in Eritrea: An investigation of reported false negative RDT results. Malar J. 2017;16(1). DOI: 10.1186/s12936-017-1752-9.
20. Organización Mundial de la Salud. Informe mundial de malaria 2021 [Internet]. Ginebra: OMS; 2021 [citado 10/11/2023]. Disponible en: https://cdn.who.int/media/docs/default-source/malaria/world-malaria-reports/world-malaria-report-2021-global-briefing-kit-spa.pdf?sfvrsn=8e5e915_23&download=true
21. Vivas Vitora ND, Alvarado Carrillo GD, Araque Rodríguez BP. Prevalencia de malaria y utilidad de las pruebas de diagnóstico rápido en Playa Colorada. Una investigación de CUMIS UCV. Bol Venez Infectol [Internet]. 2021 [citado 13/11/2022];32(2):150-9. Disponible en: http://saber.ucv.ve/ojs/index.php/rev_bvi/article/view/23507
22. Walker IS, Rogerson SJ. Pathogenicity and virulence of malaria: sticky problems and tricky solutions. Virulence. 2023;14(1). DOI: 10.1080/21505594.2022.2150456.
23. Nieto Zelaya VG, Alvarado Claros VG, García J, et al. Escolar con malaria por Plasmodium falciparum de África: riesgo para la salud pública en Honduras. Rev Méd Hondur [Internet]. 2019 [citado 13/11/2022];87(1):20-6. Disponible en: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1049487
24. Carmona-Fonseca J, Franco Gallego A, Arango Flórez E, et al. Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia). IATREIA [Internet]. 2010 [citado 13/11/2022];23(2):137-45. Disponible en: https://www.redalyc.org/articulo.oa?id=180519015005
25. Daniels JP. Increasing malaria in Venezuela threatens regional progress. Lancet Infect Dis [Internet]. 2018 [citado 13/11/2022];18(3):257. Disponible en: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30086-0/fulltext
Downloads
Published
How to Cite
Issue
Section
License
All content published in this journal is Open Access, distributed under the terms of the CC BY-NC 4.0 License.
It allows:
- Copy and redistribute published material in any medium or format.
- Adapt the content.
This will be done under the following terms:
- Attribute the authors' credits and indicate whether changes were made, in which case it must be in a reasonable way.
- Non-commercial use.
- Recognize the journal where it is published.
The copyrights of each article are maintained, without restrictions.