Early-stage squamous cell carcinoma of the glottal larynx, therapeutic update
Keywords:
laryngeal carcinoma, early stage, treatment, surgery, radiotherapy, survivalAbstract
Glottal laryngeal cancer is the most curable of all lesions that occur in the upper aerodigestive system, when treated appropriately. There are risk factors that lead to cellular changes necessary for the production of cancer, such as smoking and alcoholism. The objective is to contribute to the knowledge of the scientific community regarding the current treatment of squamous cell carcinoma of the glottal larynx in the early stage. A systematic review of the medical literature available in the databases EBSCO, SciELO, Scopus, PubMed, oncology, radiotherapy and otorhinolaryngology journals was carried out; as well as articles shared on academic social networks, such as ResearchGate. Several articles published in Spanish and English were accessed at different times during the last five years. The descriptors used were: laryngeal carcinoma, early stage, treatment, surgery, radiotherapy, and survival, in both languages. The treatment of laryngeal cancer has changed significantly in recent years due to the development of laryngeal conservation procedures such as the development of new radiotherapy techniques that ensure cure with the least possible toxicity, as well as the introduction of new medications such as therapies directed at molecular targets. Multidisciplinary management through a coordinated oncology team improves patient care, quality of life, and the possibility of preserving the larynx.
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References
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17. Wolf GT, Fisher SG, Hong WK, et al. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991;324(24):1685-90. DOI: 10.1056/NEJM199106133242402.
18. Ghoshal S, Bhattacharyya T, Dhanireddy B, et al. Efficacy of radical radio-therapy alone for functional preservation of larynx in laryngeal carcinoma: A retrospective analysis. Indian J Cancer. 2014;51(1):10-4. DOI: 10.4103/0019-509X.134600.
19. Grant DG, Salassa JR, Hinni ML, et al. Transoral laser microsurgery for recurrent laryngeal and pharyngeal cancer. Otolaryngol Head Neck Surg. 2008;138(5):606-13. DOI: 10.1016/j.otohns.2007.12.046.
20. Mehanna H, Robinson M, Hartley A, et al. Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Lancet [Internet]. 2019 [citado 21/03/2024];393(10166):51-60. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/30449623
21. Yamazaki H, Nishiyama K, Tanaka E, et al. Radiotherapy of early gloticccarci nom a (T1N0M0): results of prospective randomized study of radiation size and overall treatment time. Int J Radiat Oncol Biol Phys. 2006;64(1):77-82. DOI: 10.1016/j.ijrobp.2005.06.014.
22. Peretti G, Nicolai P, Piazza C, et al. Oncological results of endoscopic resections of TIS and T1 glottic carcinomas by carbon dioxide laser. Ann Otol Rhinol Laryngol. 2001;110(9):820-6. DOI: 10.1177/000348940111000904.
23. Rodel RM, Steiner W, Muller RM, et al. Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure. Head Neck [Internet]. 2009 [citado 04/06/2023];31(5):583-92. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/19132720
24. Texakalidis P, Giannopoulos S, Tsouknidas I, et al. Prevalence of carotid stenosis following radiotherapy for head and neck cancer: a systematic review and meta-analysis. Head Neck [Internet]. 2020 [citado 04/06/2023];42:1077-88. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/32048781
25. De Virgilio A, Costantino A, Mercante G, et al. Transoral robotic surgery and intensity-modulated radiotherapy in the treatment of the oropharyngeal carcinoma: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol [Internet]. 2021 [citado 04/06/2023];278(5):1321-35. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/32696250
26. Lugo Machado JA. Frecuencia, aspectos clínicos y factores asociados al cáncer de laringe. Acta otorrinolaringol Cir Cabeza Cuello [Internet]. 2018 [citado 30/05/2021];45(4):240-6. Disponible en: https://revista.acorl.org.co/index.php/acorl/article/view/78
27. Wang P, Zhang M, Ke C, et al. The efficacy and toxicity of induction chemotherapy plus concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: a meta-analysis of randomized controlled trials. Medicine (Baltimore) [Internet]. 2020 [citado 04/06/2023];99(10):e19360. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/32150078
28. Lee TH, Lee JH, Kwon SK, et al. Hypofractionated radiotherapy for early stage glottic cancer: efficacy of 3.5 Gy per fraction. Radiat Oncol J. 2022;40(2):120-6. DOI: 10.3857/roj.2021.01025.
29. Omar-Robert Z, Camejo-Carbonell A, Neyra-Barros R. Características clínico epidemiológicas de pacientes con cáncer de laringe. MEDISAN [Internet]. 2020 [citado 04/06/2023];24(1) :[aprox. 7 pantallas]. Disponible en: https://medisan.sld.cu/index.php/san/article/view/2863
30. Henriques De Figueiredo B, Fortpied C, Menis J, et al. Long-term update of the 24954 EORTC phase III trial on larynx preservation. Eur J Cancer [Internet]. 2016 [citado 04/06/2023];65:109-12. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27494036/
2. Gavid M, Prades JM. Cáncer de laringe. EMC-Otorrinolaringología. 2020;49(3). DOI: 10.1016/S1632-3475(20)43999-2.
3. Carías-Díaz J, Naira D, Dubón J, et al. Factores predisponentes, antecedentes patológicos, clínica, histología e imagenología por banda estrecha en el cáncer laríngeo. Rev Cubana Otorrin Laringol Cabeza y Cuello [Internet]. 2020 [citado 04/06/2023];4(3). Disponible en: https://revotorrino.sld.cu/index.php/otl/article/view/164
4. Yom SS, Torres-Saavedra P, Caudell JJ, et al. Reduced-dose radiation therapy for HPV-associated oropharyngeal carcinoma (NRG Oncology HN002). J Clin Oncol [Internet]. 2021 [citado 04/06/2023];39(9):956-65. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/33507809
5. Santana Álvarez J, Acosta Abréu G, Miranda Ramos M, et al. Eficacia de la radioterapia en los pacientes con cáncer laríngeo en estadio I y II. Arch méd Camagüey [Internet]. 2018 [citado 21/03/2024];22(6):725-42. Disponible en: https://revistaamc.sld.cu/index.php/amc/article/view/5801
6. Gourin CG, Stewart CM, Frick KD, et al. Association of hospital volume with laryngectomy outcomes in patients with larynx cancer. JAMA Otolaryngol Head Neck Surg [Internet]. 2019 [citado 04/06/2023];145(1):62-70. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/30476965
7. Meireles-López L. Caracterización de pacientes con carcinoma epidermoide laríngeo. Rev Cubana Otorrin Laringol Cabeza y Cuello [Internet]. 2019 [citado 21/03/2024];3(3). Disponible en: https://revotorrino.sld.cu/index.php/otl/article/view/107
8. Obid R, Redlich M, Tomeh C. The treatment of laryngeal cancer. Oral Maxillofac Surg Clin N Am. 2019;31(1):1-11. DOI: 10.1016/j.coms.2018.09.001.
9. Cabrales-Fuentes J, Mendoza-Cabalé A, García-Castillo A. Sistemática imagenológica para el abordaje del tumor laríngeo. Rev Cubana Otorrin Laringol Cabeza y Cuello [Internet]. 2023 [citado 21/03/2024];7(3) Disponible en: https://revotorrino.sld.cu/index.php/otl/article/view/412
10. Abreu Ruiz G, Bermejo Bencomo W, Romero Pérez Td, et al. El proceso para la nueva organización del control del cáncer en Cuba. Infodir [Internet]. 2022 [citado 21/03/2024];0(37). Disponible en: https://revinfodir.sld.cu/index.php/infodir/article/view/1001
11. Contreras-Álvarez P, Iznaga-Marín N, Hernández-Armstrong L, et al. Tratamiento con radioterapia en pacientes con neoplasia laríngea. Rev Cubana Otorrin Laringol Cabeza y Cuello [Internet]. 2020 [citado 21/03/2024];4(1) Disponible en: https://revotorrino.sld.cu/index.php/otl/article/view/130
12. Bory Porra L, Sánchez Azcuy Y, Ortiz Benet R, et al. Cáncer de Laringe precoz en estadio temprano. Rev Ciencias Médicas [Internet]. 2019 [citado 24/09/2023];23(4):553-61. Disponible en: http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3912
13. Bonomo P, Greto D, Desideri I, et al. Clinical outcome of stereotactic body radiotherapy for lung-only oligometastatic head and neck squamous cell carcinoma: Is the deferral of systemic therapy a potential goal? Oral Oncol [Internet]. 2019 [citado 21/03/2024];93:1-7. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/31109688
14. Magnano M, Cavalot AL, Gervasio CF, et al. Surgery or radiotherapy for early stages carcinomas of the glottic larynx. Tumori. 1999;85(3):188-93. DOI: 10.1177/030089169908500308.
15. Ferlito A, Bradley PJ, Rinaldo A. What is the treatment of choice for T1 squamous cell carcinoma of the larynx? J Laryngol Otol. 2004;118(10):747-9. DOI: 10.1258/0022215042450760.
16. Gillison ML, Trotti AM, Harris J, et al. Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial. Lancet [Internet]. 2019 [citado 21/03/2024];393(10166):40-50. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/30449625
17. Wolf GT, Fisher SG, Hong WK, et al. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. 1991;324(24):1685-90. DOI: 10.1056/NEJM199106133242402.
18. Ghoshal S, Bhattacharyya T, Dhanireddy B, et al. Efficacy of radical radio-therapy alone for functional preservation of larynx in laryngeal carcinoma: A retrospective analysis. Indian J Cancer. 2014;51(1):10-4. DOI: 10.4103/0019-509X.134600.
19. Grant DG, Salassa JR, Hinni ML, et al. Transoral laser microsurgery for recurrent laryngeal and pharyngeal cancer. Otolaryngol Head Neck Surg. 2008;138(5):606-13. DOI: 10.1016/j.otohns.2007.12.046.
20. Mehanna H, Robinson M, Hartley A, et al. Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Lancet [Internet]. 2019 [citado 21/03/2024];393(10166):51-60. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/30449623
21. Yamazaki H, Nishiyama K, Tanaka E, et al. Radiotherapy of early gloticccarci nom a (T1N0M0): results of prospective randomized study of radiation size and overall treatment time. Int J Radiat Oncol Biol Phys. 2006;64(1):77-82. DOI: 10.1016/j.ijrobp.2005.06.014.
22. Peretti G, Nicolai P, Piazza C, et al. Oncological results of endoscopic resections of TIS and T1 glottic carcinomas by carbon dioxide laser. Ann Otol Rhinol Laryngol. 2001;110(9):820-6. DOI: 10.1177/000348940111000904.
23. Rodel RM, Steiner W, Muller RM, et al. Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure. Head Neck [Internet]. 2009 [citado 04/06/2023];31(5):583-92. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/19132720
24. Texakalidis P, Giannopoulos S, Tsouknidas I, et al. Prevalence of carotid stenosis following radiotherapy for head and neck cancer: a systematic review and meta-analysis. Head Neck [Internet]. 2020 [citado 04/06/2023];42:1077-88. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/32048781
25. De Virgilio A, Costantino A, Mercante G, et al. Transoral robotic surgery and intensity-modulated radiotherapy in the treatment of the oropharyngeal carcinoma: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol [Internet]. 2021 [citado 04/06/2023];278(5):1321-35. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/32696250
26. Lugo Machado JA. Frecuencia, aspectos clínicos y factores asociados al cáncer de laringe. Acta otorrinolaringol Cir Cabeza Cuello [Internet]. 2018 [citado 30/05/2021];45(4):240-6. Disponible en: https://revista.acorl.org.co/index.php/acorl/article/view/78
27. Wang P, Zhang M, Ke C, et al. The efficacy and toxicity of induction chemotherapy plus concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: a meta-analysis of randomized controlled trials. Medicine (Baltimore) [Internet]. 2020 [citado 04/06/2023];99(10):e19360. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/32150078
28. Lee TH, Lee JH, Kwon SK, et al. Hypofractionated radiotherapy for early stage glottic cancer: efficacy of 3.5 Gy per fraction. Radiat Oncol J. 2022;40(2):120-6. DOI: 10.3857/roj.2021.01025.
29. Omar-Robert Z, Camejo-Carbonell A, Neyra-Barros R. Características clínico epidemiológicas de pacientes con cáncer de laringe. MEDISAN [Internet]. 2020 [citado 04/06/2023];24(1) :[aprox. 7 pantallas]. Disponible en: https://medisan.sld.cu/index.php/san/article/view/2863
30. Henriques De Figueiredo B, Fortpied C, Menis J, et al. Long-term update of the 24954 EORTC phase III trial on larynx preservation. Eur J Cancer [Internet]. 2016 [citado 04/06/2023];65:109-12. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27494036/
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2024-07-31
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González-García M, Alfonso-Alfonso Y, García-Hernández M. Early-stage squamous cell carcinoma of the glottal larynx, therapeutic update. Rev Méd Electrón [Internet]. 2024 Jul. 31 [cited 2025 Jan. 23];46:e5669. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/5669
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