Dietary supplement-induced hepatotoxicity: clinical, regulatory, and public health challenges
Keywords:
drug-related side effects and adverse reactions, substance- and drug-induced liver disease, dietary supplements, liver transplantationAbstract
Hepatotoxicity caused by dietary and herbal supplements is addressed. This article aims to discuss the relevant aspects underlying the diagnosis and the factors associated with toxic hepatitis. The vulnerability of the liver is highlighted, along with the difficulty of diagnosing and treating the condition. Clinical and diagnostic cases are also explored, noting that many patients recover, although some eventually require a transplant or face death. Additionally, factors associated with hepatotoxicity are mentioned, such as bioactive compounds in various supplements and the lack of regulation of their composition. Other clinical and regulatory considerations emphasize the need for improvement in diagnosis, regulation, and physician-patient communication. It is concluded that there is an urgent to strengthen health controls, professionals training, as well as consumer awareness about the risks of dietary and herbal supplements, so as to reduce their consumption and lessen the impact on liver health.
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