Immunotherapy employment in patient with infection produced by Staphylococcus aureus

Authors

  • Sandra Adela Naranjo Rodríguez Universidad de Ciencias Médicas de Matanzas
  • Rodobaldo García Menéndez Hospital Universitario Clínico-Quirúrgico Comandante Faustino Pérez. Matanzas
  • Lisandra Naranjo Rodríguez Centro Provincial de Higiene, Epidemiología y Microbiología. Matanzas
  • Marisel Negret Hernández Universidad de Ciencias Médicas de Matanzas

Keywords:

skin diseases infectious, Staphylococcus aureus, immunotherapy, autovaccines, clinical trial phase II, treatment outcome

Abstract

The skin infection by Staphylococcus aureus is currently a health problem in our population, because of its high frequency, resistance to the antibiotic therapy and its complications. We carried out a randomized, open, controlled, phase II clinical trial, with the objective of demonstrating the therapeutic effect and safety of the autovaccine as a treatment of the Staphylococcus infections. 457 patients with a diagnosis of Staphylococcus aureus in skin lesions were included, and they were divided in two groups. Group A (237 patients), received the autovaccine obtained form the micro organism isolated in each subject, and group B (220 patients), received antibiotic treatment according to the antibiogram results. With the application of the autovaccine, we obtained 82 % of healing, and only 10 % of the patients had the reappearance of furuncles in an interval of 6 months after finishing the treatment. However, with the application of the antibiotic therapy there was 12 % of healing and 75 % of reappearance of the furuncles in the mentioned time interval. The autovaccine was more effective in the treatment of the bacterial infection by Staphylococcus aureus that the antimicrobial agents besides being a good tolerated immunotherapy for most of the patients.

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How to Cite

1.
Naranjo Rodríguez SA, García Menéndez R, Naranjo Rodríguez L, Negret Hernández M. Immunotherapy employment in patient with infection produced by Staphylococcus aureus. Rev Méd Electrón [Internet]. 2014 Mar. 27 [cited 2025 Apr. 13];33(2):188-94. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/824

Issue

Vol. 33 No. 2 (2011)

Section

Research article

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