Recurrent laryngeal papillomatosis with multidiscipline follow-up. A propos of a case

Abstract

Laryngeal papillomatosis is a disease produced by the human papillomavirus, frequently affecting the vocal cords, epiglottis, and also the ventricular bands, that may extend to the entire organ. The disease has an unpredictable course and the pulmonary extension and malignant transformation has been reported. In the clinic-surgical otorhinolaryngological practice it is a challenge to achieve an adequate manage of the patient when the evolution tends to recidivisms. The case of a female patient aged 53 years was presented; she had no record of previous disease, and was diagnosed of laryngeal papillomatosis, being treated with human recombinant Interferon∞2b and laryngeal microsurgeries. In a period of 4 months, she presented 6 recidivisms: the first five of them mediated by 10-15 days, and the 6ths one a month after the precedent. The sequence used for the study was enounced, including the dosage of interferon antibodies, serologic studies searching for concomitance with other viruses, viral typing, dosage of immunoglobulins and complements. Besides that, it was carried out a proposal of clinical follow-up taking into account the lesions status and level. It was evidenced the importance of the multidiscipline management of the patient by immunologists, infection diseases specialists, otolaryngologists and phoniatrists for his/her total recuperation.