Erythromelalgia. Case Report

Authors

Keywords:

erythromelalgia, flushing, burning pain, mutation, aspirin.

Abstract

Erythromelalgia is a rare, chronic, little known disease, of difficult diagnosis and treatment. It is characterized by redness, heat, and intense pain and burning in the distal part of the extremities. It mainly affects hands, feet, nose and ears. The flushing, pain and warmth of the extremities increase when exposed to high temperatures as well as after exercise. The symptoms are usually relieved by immersing the affected limb in cold water. The authors present the case of a white, 33-years-old woman, with predominantly involved hand. Through a detailed interview and complementary tests they concluded that the etiological variant presented by the patient was a primary or idiopathic erythromelalgia. Treatment with aspirin and nifedipine was prescribed; the clinical progress of the patient was successful.


Downloads

Download data is not yet available.

References

1.- Mitchell SW. On a rare vasomotor neurosis of the extremities and on the maladies with which it may be confounded. Am J Med Sci [Internet]. 1878[citado 20/03/19]; 76: 2-36. Disponible en: https://www.readcube.com/articles/10.1097/00000441-187815100-00001

2.- Mann N, King T, Murphy R. Review of primary and secondary erythromelalgia. Clin Exp Dermatol. 2019 Jul;44(5):477-82. Epub 2019 Jan 4. Citado en PubMed; PMID: 30609105.

3.- Gil F. P. Luísb, M. Duarte, et al. Eritromelalgia secundaria: informe de caso. Actas Dermosifiliogr[Internet].2020;xxx(xx):xxx---xxx. Disponible en: https://www.actasdermo.org/es-pdf-S0001731020302222

4.- Leroux MB, Carbo E. Manejo racional de la eritromelalgia. Act Terap Dermatol [Internet]. 2010[citado 20/03/19]; 33:126. Disponible en: https://www.researchgate.net/publication/306392597

5.- Davis MDP. Erythromelalgia. UptoDate [Internet].2016 [citado 20/03/19]. Disponible en: https://www.uptodate.com/contents/erythromelalgia/print

6.- Kalgaard OM, Seem E, Kvernebo K. Erythromelalgia: a clinical study of 87 cases. J Intern Med. 1997 Sep;242(3):191-7. Citado en PubMed PMID: 9350163.

7.- Alhadad A, Wollmer P, Svensson A, et al. Erythromelalgia: Incidence and clinical experience in a single centre in Sweden. Vasa. 2012 Jan;41(1):43-8. Citado en PubMed; PMID: 22247059.

8.- Reed KB, Davis MD. Incidence of erythromelalgia: a population-based study in Olmsted County, Minnesota. J Eur Acad Dermatol Venereol. 2009 Jan [citado 20/03/19];23(1):13-5. Citado en PubMed; PMID: 18713229; PMCID: PMC2771547.

9.- De Diego MC, Buso C, Bonavia P, et al. Eritromelalgia primaria: comunicación de dos casos familiares. Dermatol Argent [Internet]. 2013[citado 20/03/19]; 19(5): 347-49. Disponible en: https://www.dermatolarg.org.ar/index.php/dermatolarg/article/view/666/0

10.- Wu B, Zhang Y, Tang H, et al. A Novel SCN9A Mutation (F826Y) in Primary Erythromelalgia Alters the Excitability of Nav1.7. Curr Mol Med. 2017;17(6):450-7. Citado en PubMed; PMID: 28990532.

11.- Zhang Z, Schmelz M, Segerdahl M, et al. Exonic mutations in SCN9A (NaV1.7) are found in a minority of patients with erythromelalgia. Scand J Pain. 2014 Oct 1;5(4):217-25. Citado en PubMed; PMID: 29911575.

12.- Tang Z, Chen Z, Tang B, et al. Primary erythromelalgia: a review. Orphanet J Rare Dis. 2015 Sep 30; 10:127. Citado en PubMed; PMID: 26419464; PMCID: PMC4589109.

13.- Parker LK, Ponte C, Howell KJ, et al. Clinical features and management of erythromelalgia: long term follow-up of 46 cases. Clin Exp Rheumatol. 2017 Jan-Feb;35(1):80-4. Citado en PubMed; PMID: 27494156.

14.- Klein-Weigel PF, Volz TS, Richter JG. Erythromelalgia. Vasa. 2018 Feb;47(2):91-97. Epub 2018 Jan 4. Citado en PubMed; PMID: 29299961.

15.- López L, Asz Sigall D, Vázquez Velo JA, et al. Eritromelalgia. Informe de un caso clínico. Med Int Mex [Internet]. 2007; 23:251-55. Disponible en: https://www.medigraphic.com/pdfs/medintmex/mim-2007/mim073n.pdf

16.- Leroux MB. Erythromelalgia: a cutaneous manifestation of neuropathy? An Bras Dermatol. 2018 Jan-Feb;93(1):86-94. Citado en PubMed; PMID: 29641704; PMCID: PMC5871369.

17.- Vanwonterghem Y, Shadid S. Simvastatin-induced erythromelalgia: less is more. Acta Clin Belg. 2019 Jul 10:1-2. Epub ahead of print. Citado en PubMed; en PMID: PMID: 31291834.

18.- Tham SW, Giles M. Current pain management strategies for patients with erythromelalgia: a critical review. J Pain Res. 2018 Aug 30; 11:1689-1698. Citado en PubMed; PMID: 30214279; PMCID: PMC6121769.

19.- Sharif S. Primary Erythromelalgia Complicated by Cellulitis: A Case Report and Review of Literature. Am J Med Case Rep. 2020; 8(6): 153–8. Citado en PubMed; PMID: 32490173.

20.- Tham SW, Giles M. Current pain management strategies for patients with erythromelalgia: A critical review. J Pain Res. 2018:11. Citado en PubMed; PMID: 30214279.

Downloads

Published

2020-11-10

How to Cite

1.
Febles Sanabria RJ, Garcia Herrera AL, Rodriguez Pereira M, Carreño Rolando IE, Pérez Martín O. Erythromelalgia. Case Report. Rev Méd Electrón [Internet]. 2020 Nov. 10 [cited 2025 Jan. 10];42(6):1-8. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/3295

Issue

Vol. 42 No. 6 (2020)

Section

Presentation of cases

License

All content published in this journal is Open Access, distributed under the terms of the CC BY-NC 4.0 License.

It allows:

 - Copy and redistribute published material in any medium or format.

 - Adapt the content.

 This will be done under the following terms:

 - Attribute the authors' credits and indicate whether changes were made, in which case it must be in a reasonable way.

 - Non-commercial use.

 - Recognize the journal where it is published.

 The copyrights of each article are maintained, without restrictions.

Most read articles by the same author(s)

1 2 > >>