Immune response in patients diagnosed with leprosy

Authors

Keywords:

immune response, Hansen’s disease, reactional states, erythema nudosum leprosum

Abstract

Introduction: Leprosy is a floridly expressed entity with frequent involvement of the cutaneous integument and peripheral nerves due to the predisposition of Mycobacterium leprae to these structures. Leprosy reactions may appear during the course of the disease. These interrupt the usual chronic course and the clinical stability of patients suffering from the disease.

Objective: To characterize the reactional states of leprosy.

Materials and methods: A descriptive study was carried out from January 2019 to September 2022 in patients who attended the Provincial Leprosy Clinic at the Clinical Surgical University Hospital Comandante Faustino Pérez Hernández, in Matanzas. The universe consisted of 8 patients who presented reactional states in the aforementioned stage. The variables, collected from the clinical records, were: age, sex; classification of leprosy according to Ridley-Jopling, type of reactional state, clinical form and time of onset.

Results: The highest frequency was between 50 and 64 years, with 50%. The male sex represents 62.5%. Lepromatous leprosy prevalence was shown in 62.5%. The type II reaction and severe forms were the most frequent with 62.5% and 75% respectively. There was predominance of leprosy reactions during and after treatment without differences between them, with 37.5%.

Conclusions: The type II reaction with severe forms of presentation was predominant in male patients represented in the age group of 50 to 64 years. The predominant clinical form in these events was the lepromatous one.

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Published

2023-09-18

How to Cite

1.
Darias-Domínguez C, Velázquez-Sánchez A, De Vegas-Ascanio L, Piña-Rodríguez Y. Immune response in patients diagnosed with leprosy. Rev Méd Electrón [Internet]. 2023 Sep. 18 [cited 2025 Jan. 22];45(5):e5325. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/5235

Issue

Vol. 45 No. 5 (2023)

Section

Research article

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