Anti-inflammatory potential of Musa spp. ABB plantain for the production of phytopharmaceuticals
Keywords:
Musa ssp. ABB group, inflammation, pharmacological effects, secondary metabolitesAbstract
Plantains belonging to the genus Musa spp. ABB have been used for the treatment of infection and pain. The search for anti-inflammatories of natural origins, more than an alternative, is a complementary therapy for the treatment of inflammation, since non-steroidal anti-inflammatories are the most used for acute or chronic inflammatory diseases, but at the same time they present gastrointestinal, cardiovascular and renal side effects, so their prolonged use is not recommended. In this paper, updated information is provided on the pharmacological effects and secondary metabolites of the Musa ssp. ABB group, for its use in elaborating an anti-inflammatory drug. The procedures carried out include documental and bibliographic analysis —in databases—of scientific articles, doctoral theses and scientific communications; the information record and preparation of the article taking into account the information updating and the sites where it is supported. From aqueous and alcoholic extracts of the plant, the following effects were proven: anti-inflammatory, antioxidant, analgesic, gastro-protective, inmuno-modulator, antidiabetic, anticancer, antibacterial, antiviral, lipid-lowering, antidiarrheal, antihypertensive, hepatoprotective, healing, anti-ulcerative and antifungal. The anti-inflammatory and antioxidant effects are related to the presence of phenols, phenolic acids, flavonoids, phytosterols and carotenes. The use of Musa spp. ABB group in drugs is very limited, therefore the proposal of developing an anti-inflammatory cream to treat multiple inflammatory diseases.Downloads
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References
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25. Boffill Cárdenas M, Martín Calero MJ. Mecanismos del efecto gastroprotector de la pulpa del fruto verde de la Musa ABB. Medicentro Electrónica [Internet]. 2018 ene-mar [citado 12/02/2022];22(1):45-52. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttex&pid=S1029-30432018000100006&Ing=es&nrm=iso
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2. Zheng Z, Johansson H, Harvey NC, et al. Potential Adverse Effect of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) on Bisphosphonate Efficacy: An Exploratory Post Hoc Analysis from a Randomized Controlled Trial of Clodronate. J Bone Miner Res. 2022;37(6):1117-24. Citado en PubMed; PMID: 35441396.
3. Tornero-Crespo MM, Montero-Matamala A. Revisión del tratamiento farmacológico del dolor secundario a artrosis con paracetamol, antinflamatorios no esteroideos clásicos (AINE) y los inhibidores selectivos de la ciclooxigenasa tipo 2 (COXIB). Rev Soc Esp Dolor [Internet]. 2021 [citado 05/05/2022];8(Supl. 1). Disponible en: https://dx.doi.org/10.20986/resed.2021.3864/2020
4. Dávila E, Morejón JM, Acosta E. Dolor y analgésicos. Algunas consideraciones oportunas. Medisur [Internet]. 2020 [citado 21/09/2022];18(4). Disponible en: http://medisur.sld.cu/index.php/medisur/article/view/4742
5. Baena-Nieto G, Vílchez-López FJ, Cornejo-Domínguez JM. Protocolo de evaluación y manejo de efectos adversos del tratamiento esteroideo [Internet]. 2020 [citado 05/05/2022];13(19):1109-12. Disponible en: https://doi.org/10.1016/j.med.2020.10.017Get
6. Laseca-Arranz A, Sánchez-Dengra B, Bermejo-Sanz M, et al. Formulaciones para la cicatrización de heridas, presente y futuro. Rev Esp Cien Farm [Internet]. 2021 [citado 18/09/2022];2(1):1-12. Disponible en https://dialnet.unirioja.es/servlet/articulo?codigo=808428
7. Sabaté LR, Diego L, Díez C, et al. Uso seguro de medicamentos tópicos I: corticosteroides. FMC [Internet]. 2022 [citado 18/09/2022];29(2):94-100. Disponible en: https://doi.org/10.1016/j.fmc.2021.07.002
8. Sharma D, Duarah R, Manash Pratim S, et al. Comprehensive Review on Different Parts of North Eastern Banana (Musa) Varieties: Phytochemical and Pharmacological Study [Internet].. En: Research Trends in Horticulture Sciences. New Delhi: Akinik Publication; 2020. [citado 14/08/2022]. Disponible en: https://doi.org/10.22271/ed.book.91
9. Lopes S, Vanz Borges C, Manso de Sousa Cardoso S, et al. Banana (Musa spp.) as a Source of Bioactive Compounds for Health Promotion. Cap. 12. En: Siddiq M, Ahmed J, Lobo MG, eds. Handbook of Banana Production, Postharvest Science, Processing Technology, and Nutrition [Internet]. New Jersey: John Wiley & Sons; 2020 [citado 18/09/2022]. Disponible en: https://doi.org/10.1002/9781119528265.ch12
10. Apriani EF, Miksusanti M, Fransiska N. Formulation and Optimization Peel-Off Gel Mask with Polyvinyl Alcohol and Gelatin Based Using Factorial Design from Banana Peel Flour (Musa paradisiaca L) As Antioxidant. Indonesian Journal of Pharmacy. 2022;33(2):261-8. https://doi.org/10.22146/ijp.3408
11. Budi HS, Anitasari S, Ulfa NM, et al. Topical Medicine Potency of Musa paradisiaca var. sapientum (L.) kuntze as Oral Gel for Wound Healing: An In Vitro, In Vivo Study. Eur J Dent. 2022;16(4). Citado en PubMed; PMID: 35181871.
12. Cruz Arzola D, coord. Formulario nacional de fitofármacos y apifármacos. La Habana: Editorial Ciencias Médicas; 2010.
13. Pereira Martínez ML, Cogollo Rojas MA. Efecto antibacteriano del cannabis no psicoactivo sobre microorganismos asociados a infecciones endodónticas. Revisión sistemática [tesis en Internet]. Cartagena de Indias: Universidad de Cartagena; 2022 [citado 02/10/2022]. Disponible en: https://repositorio.unicartagena.edu.co/handle/11227/15354
14. Chen S, Lin R, Lu H, et al. Effects of phenolic acids on free radical scavenging and heavy metal bioavailability in kandelia obovata under cadmium and zinc stress. Chemosphere. 2020;249:126341. Citado en PubMed; PMID: 32213393.
15. Roychoudhury A, Bhowmik R. Understanding the Mechanistic Functioning of Bioactive Compounds in Medicinal Plants. En: Aftab T, Hakeem KR, eds. Medicinal and Aromatic Plants. Healthcare and Industrial Applications. EE. UU.: Springer; 2021. p. 159-84.
16. Kaur N, Ahmed T. Bioactive Secondary Metabolites of Medicinal and Aromatic Plants and Their Disease-Fighting Properties. En: Aftab T, Hakeem KR, eds. Medicinal and Aromatic Plants. Healthcare and Industrial Applications. EE. UU.: Springer; 2021. p. 113-42.
17. Salehi B, Quispe C, Sharifi-Rad J, et al. Phytosterols: From Preclinical Evidence to Potential Clinical Applications. Front Pharmacol. 2021;11:599959. Citado en PubMed; PMID: 33519459.
18. Dash R, Mitra S, Ali MC, et al. Phytosterols: Targeting Neuroinflammation in Neurodegeneration. Curr Pharm Des. 2021;27(3):383-401. Citado en PubMed; PMID: 32600224.
19. Zia-Ul-Haq M, Riaz M, Alotaibi M. Carotenoids and Bone Health. En: Zia-Ul-Haq M, Dewanjee S, Riaz M, ed. Carotenoids: Structure and Function in the Human Body [Internet]. Switzerland: Springer Nature; 2021 [citado 18/09/2022]. Disponible en: https://doi.org/10.1007/978-3-030-46459-2_21
20. Maoka T. Carotenoids as natural functional pigments. J Nat Med. 2020;74(1):1-16. Citado en PubMed; PMID: 31588965.
21. Rodríguez-Rodríguez E, Estévez-Santiago R, Sánchez-Prieto M, et al. Status and Dietary Intake of Phytoene and Phytofluene in Spanish Adults and the Effect of a Four-Week Dietary Intervention with Lutein-Rich Fruits or Vegetables. Nutrients [Internet]. 2022 [citado 25/08/2022];14:(2922). Disponible en: https://doi.org/10.3390/nu14142922
22. Tarshish E, Hermoni K, Sharoni Y, et al. Effect of Lumenato oral supplementation on plasma carotenoid levels and improvement of visual and experiential skin attributes. J Cosmet Dermatol. 2022;21(9):4042-52. Citado en PubMed; PMID: 35020247.
23. Ibazeta Alvarado CF, Pimentel Chavez YG. Efecto cicatrizante del gel a base de Musa acuminata colla. (cáscara de plátano) en heridas superficiales inducidas en ratones albinos [tesis en Internet]. Lima: Universidad Inca Garcilaso de la Vega; 2018 [citado 25/08/2022]. Disponible en: http://repositorio,uigv.edu.pe/handle/20.500.11818/2428
24. Pons Pérez C, González Díaz L, Molina Concepción O, et al. Tecnologías para cultivares de Musa spp. sobre soporte digital para una agricultura sostenible. Rev Agricultura Tropical. 2018;4(1):51-8.
25. Boffill Cárdenas M, Martín Calero MJ. Mecanismos del efecto gastroprotector de la pulpa del fruto verde de la Musa ABB. Medicentro Electrónica [Internet]. 2018 ene-mar [citado 12/02/2022];22(1):45-52. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttex&pid=S1029-30432018000100006&Ing=es&nrm=iso
26. Aiemcharoen P, Wichienchot S, Sermwittayawong D. Antioxidant and anti-diabetic activities of crude ethanolic extract from the banana inflorescence of musa (ABB group) namwa maliong. Functional Foods in Health and Disease [Internet]. 2022 [citado 26/06/2022];12(4):161-74. Disponible en: https://www.doi.org/10.31989/ffhd.v12i4.909
27. Drapal M, Amah D, Schöny H, et al. Assessment of metabolic variability and diversity present in leaf, peel and pulp tissue of diploid and triploid Musa spp. Phytochemistry [Internet]. 2020 [citado 18/08/2022];176 (112388). Disponible en: https://doi.org/10.1016/j.phytochem.2020.112388
28. Fernández Urquiza F, Rodríguez Treto R, Torres Fuentes M, et al. Características químico-farmacéuticas y propiedades farmacológicas de extractos de Musa ssp ABB (plátano burro). Rev Cubana Plant Med [Internet]. 1997 [citado 18/08/2022];2(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttex&pid=S1028-47961997000200009&Ing=es&nrm=iso
29. Calderín Campbell JE, Calderín Campbell E. De materia verde. Fitorerapia y apiterapia. La Habana: Editorial Científico-Técnica; 2018.
30. Peña Hernández N. Antiinflamatorios tópicos no esteroideos [tesis en Internet]. Madrid: Universidad Complutense; 2018 [citado 18/08/2022]. Disponible en: http://147.96.70.122/Web/TFG/TFG/Memoria/NATALIA%20PE%C3%91A%20HERNANDEZ.pdf
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Published
2023-02-12
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Fernández-Urquiza F, Torres-Fuentes M. Anti-inflammatory potential of Musa spp. ABB plantain for the production of phytopharmaceuticals. Rev Méd Electrón [Internet]. 2023 Feb. 12 [cited 2025 Jan. 9];45(1):e5101. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/5101
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