Presurgery medication with clonidine to attenuate the answer to the tracheal intubation.

Abstract

Laryngoscope and tracheal intubation are a strong nociceptive stimulus, able to unchain phenomena with a significant increase of arterial tension and hearth frequency. To prospective study was carried out in 40 patients ASA I-II with general anesthesia to perform a diskectomy. They were subdivided into two groups. The Group B's patients received 150 mcg (2.5 mcg/Kg) orally, 90-120 min before the induction and the Group A's patients did not receive anything. The basal and postintubation hemodynamic were evaluated. The Group B's patients showed les systolic and diastolic arterial tension than the Group A's patients. (Group A 146 ± 18 vs. 95 ± 15 mmHg versus Group B 110 ± 10 versus 72 ± 8 mm (p<0,05); the hearth frequency increased only in 11 ± 4 beats per minute in the Group B (p<0,05). Supplementary analgesia was required in a 22 % of the Group B's patients versus an 85 % of the Group A's patients. Arterial hypertension predominated in Group A (p>0, 05). The use of clonidine was excellent to minimize the adrenal sympathetic answer during the laryngoscope and tracheal intubation. Less supplementary analgesia was required in the patients who used this medicine. The use of this drug did not presented undesirable effects.