Cardiovascular reactivity as a sign of arterial stiffness in schoolchildren
Keywords:
arterial stiffness; vessel diameter; thickening of the carotid intima-media complex; arteriosclerosisAbstract
Introduction: Arterial stiffness is a measure of vascular damage and an early marker of cardiovascular risk. Its detection in school-age children is essential to prevent future complications.
Objective: To identify signs of arterial stiffness in schoolchildren with cardiovascular risk factors according to figures of blood pressure and vascular reactivity by sustained weight test.
Methods: A descriptive and cross-sectional study was carried out with a population of children aged 10-11 years, supposedly healthy. Anthropometric variables were used, and for the diagnosis of arterial stiffness, measurements of the carotid artery in cardiac systole and diastole and of the carotid intima-media complex; for measuring blood pressure and cardiovascular resistance, the sustained weight test was used.
Results: The greatest diameter and thickening of the carotid intima-media complex was observed in males. According to nutritional status, as the children were overweight or obese, were prehypertensive and hyperreactive cardiovascular, a greater thickening of the vessel wall and its diameter was observed. More than 11 children were above the 90th percentile for their age and sex, considered pathological.
Conclusions: The signs of arterial stiffness can be detected from childhood, and their percentile values are equal to or greater than 90 percentile in overweight and obese. Hyperreactive children according to the sustained weight test, and prehypertensive ones, also showed signs of arterial stiffness more frequently.
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1. Maier JA, Andrés V, Castiglioni S, et al. Aging and Vascular Disease: A Multidisciplinary Overview. J Clin Med [Internet]. 2023 [citado 02/07/2024];12(7):5512. Disponible en: https://www.mdpi.com/2077-0383/12/17/5512
2. Li A, Yan J, Zhao Y, et al. Vascular Aging: Assessment and Intervention. Clin Interv Aging [Internet]. 2023 [citado 12/07/2024];18:1373-95. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10441648/
3. Gusmão WDP, Pureza IROM, Moreno CRC, et al. Shift Work and Early Arterial Stiffness: A Systematic Review. Int J Environ Res Public Health. 2022;19(21):14569. DOI: 10.3390/ijerph192114569.
4. Salomão LP, Magalhães GS, da Silva JFP, et al. Factors associated with arterial stiffness assessed by pulse pressure amplification in healthy children and adolescents: a cross-sectional study. BMC Pediatr [Internet]. 2023 [citado 22/01/2023];23:154. Disponible en: https://link.springer.com/article/10.1186/s12887-023-03942-1
5. Hanssen H. Vascular biomarkers in the prevention of childhood cardiovascular risk: From concept to clinical implementation. Front Cardiovasc Med. 2022;9:935810. DOI: 10.3389/fcvm.2022.935810.
6. Varley BJ, Nasir RF, Craig ME, et al. Early life determinants of arterial stiffness in neonates, infants, children and adolescents: A systematic review and meta-analysis. Atherosclerosis [Internet]. 2022 [citado 12/12/2024];355:1-7. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0021915022013478
7. Sequi-Dominguez I, Mavridis D, Cavero-Redondo I, et al. Comparative effectiveness of different types of exercise in reducing arterial stiffness in children and adolescents: a systematic review and network meta-analysis. Br J Sports Med [Internet]. 2023 [citado 12/12/2024];57(15):997-1002. Disponible en: https://bjsm.bmj.com/content/57/15/997.abstract
8. Doyon A, Kracht D, Bayazit AK, et al. Carotid artery intima-media thickness and distensibility in children and adolescents: reference values and role of body dimensions. Hypertension [Internet]. 2013 [citado 12/12/2022];62(3):550-6. Disponible en: https://www.ahajournals.org/doi/epub/10.1161/HYPERTENSIONAHA.113.01297
9. Fernández-Alvarez V, Linares Sánchez M, López Alvarez F, et al. Evaluation of Intima-Media Thickness and Arterial Stiffness as Early Ultrasound Biomarkers of Carotid Artery Atherosclerosis. Cardiol Ther. 2022;11(2):231-47. DOI: 10.1007/s40119-022-00261-x.
10. Morós C, Vázquez H, Goldsman A, et al. Detección del envejecimiento vascular acelerado por ecografía carotídea en niños y adolescentes con alto riesgo vascular. Rev Hosp Niños [Internet]. 2019 [citado 12/12/2022];61(272):25-31. Disponible en: http://revistapediatria.com.ar/edicion-272-deteccion-del-envejecimiento-vascular-acelerado/
11. Esquivel M, Rubí A. Curvas nacionales de peso para la talla; su interpretación y uso en la evaluación del estado de nutrición. Rev Cubana Pediatr [Internet]. 1985 [citado 12/05/2022];57(4). Disponible en: https://revpediatria.sld.cu/index.php/ped/article/view/5619
12. Esquivel Lauzurique M, Rubén Quesada M, González Fernández C, et al. Curvas de crecimiento de la circunferencia de la cintura en niños y adolescentes habaneros. Rev Cubana Pediatr [Internet]. 2011 [citado 12/12/2022];83(1):44-55. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312011000100005&nrm=iso
13. Aguilar YR, Pérez Hidalgo ME, Riverón MR, et al. Desarrollo antropométrico en escolares de 7 a 10 años de edad en Holguín-2019. CMM [Internet]. 2021 [citado 12/04/2022];25(4). Disponible en: https://revcocmed.sld.cu/index.php/cocmed/article/view/3995/2008
14. Rodríguez Cervera CL, González Rodríguez EF, García Nóbrega Y, et al. Preparación al docente para prevenir indicadores de riesgo cardiovascular en escolares santaclareños. Edumecentro [Internet]. 2020 [citado 12/04/2022];12(1):61-81. Disponible en: http://scielo.sld.cu/pdf/edu/v12n1/2077-2874-edu-12-01-61.pdf
15. Chávez González E, González Rodríguez E, Llanes Camacho MC, et al. Dispersión de la onda p, su asociación con variables ecocardiográficas y la presión arterial en niños entre 8 a 11 años. Anales de la ACC [Internet]. 2016 [citado 12/04/2022];5(3). Disponible en: https://revistaccuba.sld.cu/index.php/revacc/article/view/307
16. Fernández Martínez E, Rodríguez Cervera CL, González Rodríguez E, et al. Obesidad y estratificación del riesgo cardiometabólico en escolares de Santa Clara. Rev Finlay [Internet]. 2022 [citado 12/12/2022];12(2):196-207. Disponible en: http://scielo.sld.cu/pdf/rf/v12n2/2221-2434-rf-12-02-196.pdf
17. Mihuta MS, Paul C, Borlea A, et al. Unveiling the silent danger of childhood obesity: non-invasive biomarkers such as carotid intima-media thickness, arterial stiffness surrogate markers, and blood pressure are useful in detecting early vascular alterations in obese children. Biomedicines [Internet]. 2023 [citado 10/10/2023];11(7):1841. Disponible en: https://www.mdpi.com/2227-9059/11/7/1841
18. Mihuta MS, Paul C, Borlea A, et al. Connections between serum Trimethylamine N-Oxide (TMAO), a gut-derived metabolite, and vascular biomarkers evaluating arterial stiffness and subclinical atherosclerosis in children with obesity. Front Endocrinol [Internet]. 2023 [citado 10/10/2023];14:1253584. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577381/pdf/fendo-14-1253584.pdf
19. Genovesi S, Tassistro E, Lieti G, et al. Wall Properties of Elastic and Muscular Arteries in Children and Adolescents at Increased Cardiovascular Risk. J Clin Med. 2023;12(21):6919. DOI: 10.3390/jcm12216919.
20. de Menezes SAT, Neco ACR, de Menezes AOD, et al. Hipertensão arterial infantil e sua relação com a obesidade: uma revisão sistemática. Braz J Health Rev [Internet]. 2023 [citado 10/10/2023];6(3):13431-49. Disponible en: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/60918/43978
21. Ferreira I, van de Laar RJ. Chapter 5 - Lessons from the Amsterdam Growth and Health Longitudinal Study. Early Vascular Aging (EVA) [Internet]. 2015 [citado 12/12/2022]:33-44. Disponible en: https://www.sciencedirect.com/science/article/pii/B9780128013878000053
22. Franklin SS, Olsen MH. Chapter 7 - Changes in Peripheral Blood Pressure with Normal and Accelerated Aging. Early Vascular Aging (EVA) [Internet]. 2015 [citado 12/12/2022]:65-73. Disponible en: https://www.sciencedirect.com/science/article/pii/B9780128013878000077
23. Bittencourt JC, Scheinbein GHA, de Oliveira Junior WC, et al. Arterial stiffness indices, pulse wave velocity and central systolic blood pressure, are able to discriminate between obese and non-obese children. Eur J Pediatr. 2023;182(3):1403-15. DOI: 10.1007/s00431-023-04807-6.
24. Heffernan K, Stoner L, Meyer ML, et al. Associations between estimated and measured carotid-femoral pulse wave velocity in older Black and White adults: the atherosclerosis risk in communities (ARIC) study. J Cardiovasc Aging [Internet]. 2022 [citado 12/12/2022];2(1). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934460/pdf/nihms-1864408.pdf
25. Jurko T, Mestanik M, Mestanikova A, et al. Early Signs of Microvascular Endothelial Dysfunction in Adolescents with Newly Diagnosed Essential Hypertension. Life (Basel). 2022;12(7):1048. DOI: 10.3390/life12071048.
26. Torres-Leyva M, Carrazana-Escalona R, Ormigó-Polo LE, et al. Respuesta autonómica cardiovascular durante la prueba isométrica cubana del peso sostenido. CorSalud [Internet]. 2019 [citado 12/04/2023];11(1):1-10. Disponible en: http://scielo.sld.cu/pdf/cs/v11n1/2078-7170-cs-11-01-1.pdf
27. Rodríguez Pena A, Guirado Blanco O, González Paz HJ, et al. Balance autonómico basal y durante el ejercicio isométrico en jóvenes con diferente reactividad cardiovascular. CorSalud [Internet]. 2019 [citado 12/04/2023];11(1):11-20. Disponible en: http://scielo.sld.cu/pdf/cs/v11n1/2078-7170-cs-11-01-11.pdf
28. León Regal ML, González Otero LH, Morffi Crespo A, et al. Relaciones fisiopatológicas entre la hiperreactividad cardiovascular, la obesidad y el sedentarismo. Rev Finlay [Internet]. 2022 [citado 12/04/2023];12(1):77-84. Disponible en: http://scielo.sld.cu/pdf/rf/v12n1/2221-2434-rf-12-01-77.pdf
29. Arenas Borda W, Lubinus Badillo F, Mantilla Suárez JC, et al. Grosor de íntima-media carotídea en niños con obesidad. Rev Colomb Radiol [Internet]. 2015 [citado 12/04/2022];26(2):4186-92. Disponible en: https://servimed.com.mx/revistavirtual/articulos/2015/septiembre/colombia/RCR_26_2_grosor_de_la_intima.pdf
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Copyright (c) 2025 Daylin Ricardo-Olivera, Alianny Rodríguez-Urrutia , Yurisandra Jiménez-González , Elibet Chávez-González
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