Evaluation of the initial chest X-ray in the management of adult patients with COVID-19

Authors

Keywords:

COVID-19, chest X-ray, radiology, validity of a diagnostic test

Abstract

Introduction: In the context of the COVID-19 pandemic, the lack of diagnostic tests or kits, together with difficulties related to sensitivity and the delay in reporting the results undermined expeditious decision-making when the patient attended the emergency services; this fact is more marked in high prevalence scenarios, which affected adequate isolation and care in general.

Objective: To evaluate the usefulness of the initial chest X-ray in the management of adult patients with COVID-19.

Methods: A cross-sectional, retrospective, analytical evaluation study was carried out in adult patients. The results of the initial chest X-ray were compared with those of the reference standard for SARS-CoV-2, and sensitivity, specificity and predictive values were used as validity indicators.

Results: The predominant radiological finding was ground-glass opacity (22.42%). Most patients had mild involvement (score 1-2), with a weighted mean severity of 1.29. 82.35% of patients with mild involvement, and 100% with moderate-severe involvement required hospitalization. Chest X-ray showed a sensitivity of 72.13% and a specificity of 12.90%, with a positive predictive value of 61.97%.

Conclusions: Initial chest X-ray in patients with COVID-19 had moderate sensitivity and low specificity, but it is useful for detecting lung involvement, guiding treatment, and predicting the need for hospitalization. Its availability and low cost make it a valuable tool, especially in resource-limited settings.

Downloads

Download data is not yet available.

References

1. World Health Organization. COVID-19 epidemiological update, edition 174, 24 December 2024 [Internet]. Geneva: World Health Organization; 2024 [citado 30/12/2024]. Disponible en: https://iris.who.int/handle/10665/379898

2. American College of Radiology. ACR recommendations for the use of chest radiography and computed tomography (CT) for suspected COVID-19 infection [Internet]. Virginia: American College of Radiology; 2020 [citado 30/10/2022]. Disponible en: https://www.acr.org/Advocacy/Position-Statements/Recommendations-for-Chest-Radiography-and-CT-for-Suspected-COVID19-Infection

3. Wong HYF, Lam HYS, Fong AH, et al. Frequency and distribution of chest radiographic findings in patients positive for COVID-19. Radiology. 2020;296(2):E72-8. DOI: 10.1148/radiol.2020201160.

4. Warren MA, Zhao Z, Koyama T, et al. Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Thorax. 2018;73(9):840-6. DOI: 10.1136/thoraxjnl-2017-211280.

5. Ochoa Sangrador C. Aprender a entender e interpretar las pruebas diagnósticas. Herramientas y aplicaciones. En: Asociación Española de Pediatría de Atención Primaria. Curso de Actualización Pediatría 2015 [Internet]. Madrid: Lúa Ediciones 3.0; 2015 [citado 12/01/2025]. Disponible en: https://www.aepap.org/sites/default/files/cursoaepap2015p255-263.pdf

6. Weinstock MB, Echenique A, Russell JW, et al. Chest x-ray findings in 636 ambulatory patients with COVID-19 presenting to an urgent care center: a normal chest x-ray is no guarantee. J Urgent Care Med [Internet]. 2020 [citado 28/12/2024];14(7):13-8. Disponible en: https://www.jucm.com/documents/jucm-CoVid-19-studyepub-april-2020.pdf

7. Shi H, Han X, Jiang N, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis [Internet]. 2020 [citado 15/12/2024];20(4):P425-34. Disponible en: https://www.thelancet.com/article/S1473-3099(20)30086-4/fulltext

8. Jacobi A, Chung M, Bernheim A, et al. Portable chest X-ray in coronavirus disease-19 (COVID-19): A pictorial review. Clin Imaging. 2020;64:35-42. DOI: 10.1016/j.clinimag.2020.04.001.

9. Parekh M, Donuru A, Balasubramanya R, et al. Review of the chest CT differential diagnosis of ground-glass opacities in the COVID era. Radiology. 2020;297(3):E289-302. DOI: 10.1148/radiol.2020202504.

10. Yasin R, Gouda W. Chest X-ray findings monitoring COVID-19 disease course and severity. Egypt J Radiol Nucl Med. 2020;51:193. DOI: 10.1186/s43055-020-00296-x.

11. Schiaffino S, Tritella S, Cozzi A, et al. Diagnostic performance of chest X-ray for COVID-19 pneumonia during the SARS-CoV-2 pandemic in Lombardy, Italy. J Thorac Imaging. 2020;35(4):W105-6. DOI: 10.1097/RTI.0000000000000533.

12. Balbi M, Caroli A, Corsi A, et al. Chest X-ray for predicting mortality and the need for ventilatory support in COVID-19 patients presenting to the emergency department. Eur Radiol. 2021;31(4):1999-2012. DOI: 10.1007/s00330-020-07270-1.

13. Nava Muñoz A, Gómez Peña S, Fuentes Ferrer ME, et al. Neumonía COVID-19: relación entre la radiografía de tórax inicial y los datos analíticos. Radiología. 2021;63(6):484-94. DOI: 10.1016/j.rx.2021.06.001.

14. Sahu AK, Dhar A, Aggarwal B. Radiographic features of COVID-19 infection at presentation and significance of chest X-ray: Early experience from a super-specialty hospital in India. Indian J Radiol Imaging. 2021;31(Supl 1):S128-33. DOI: 10.4103/ijri.IJRI_368_20.

15. Toussie D, Voutsinas N, Finkelstein M, et al. Clinical and chest radiography features determine patient outcomes in young and middle-aged adults with COVID-19. Radiology. 2020;297(1):E197-206. DOI: 10.1148/radiol.2020201754.

16. Ebrahimzadeh S, Islam N, Dawit H, et al. Thoracic imaging tests for the diagnosis of COVID-19. Cochrane Database Syst Rev. 2022;5(5):CD013639. DOI: 10.1002/14651858.CD013639.pub5.

17. Ng M, Lee EYP, Yang J, et al. Imaging profile of the COVID-19 infection: radiologic findings and literature review. Radiol Cardiothorac Imaging. 2020;2(1):e200034. DOI: 10.1148/ryct.2020200034.

18. Rubin GD, Ryerson CJ, Haramati LB, et al. The role of chest imaging in patient management during the COVID-19 pandemic: a multinational consensus statement from the Fleischner Society. Radiology. 2020;296(1):172-80. DOI: 10.1148/radiol.2020201365.

19. Peng F, Tu L, Yang Y, et al. Management and treatment of COVID-19: the Chinese experience. Can J Cardiol. 2020;36(6):915-30. DOI: 10.1016/j.cjca.2020.04.010.

20. Moroni C, Cozzi D, Albanesi M, et al. Chest X-ray in the emergency department during COVID-19 pandemic descending phase in Italy: correlation with patients' outcome. Radiol Med. 2021;126(5):661-8. DOI: 10.1007/s11547-020-01327-3.

21. Stephanie S, Shum T, Cleveland H, et al. Determinants of chest radiography sensitivity for COVID-19: a multi-institutional study in the United States. Radiol Cardiothorac Imaging [Internet]. 2020 [citado 30/12/2024];2(5):e200337. Disponible en: https://pubs.rsna.org/doi/epdf/10.1148/ryct.2020200337

22. Shah K, Kamler J, Phan A, et al. Imaging & other potential predictors of deterioration in COVID-19. Am J Emerg Med. 2020;38(7):1547.e1-4. DOI: 10.1016/j.ajem.2020.04.075.

23. Prince R, Niu Z, Khan ZY, et al. COVID-19 detection from chest X-ray images using CLAHE-YCrCb, LBP, and machine learning algorithms. BMC Bioinformatics. 2024;25(1):28. DOI: 10.1186/s12859-023-05427-5.

24. Sverzellati N, Ryerson CJ, Milanese G, et al. Chest radiography or computed tomography for COVID-19 pneumonia? Comparative study in a simulated triage setting. Eur Respir J. 2021;58(3):2004188. DOI: 10.1183/13993003.04188-2020.

25. Sáez de Gordoa E, Portella A, Escudero-Fernández JM, et al. Utilidad de la radiografía de tórax para la detección de neumonía COVID-19 durante la pandemia por SARS-CoV-2. Radiología. 2022;64(4):310-6. DOI: 10.1016/j.rx.2021.11.001.

26. El Houby EMF. COVID-19 detection from chest X-ray images using transfer learning. Sci Rep. 2024;14(1):11639. DOI: 10.1038/s41598-024-61693-0.

27. Litmanovich DE, Chung M, Kirkbride RR, et al. Review of chest radiograph findings of COVID-19 pneumonia and suggested reporting language. J Thorac Imaging. 2020;35(6):354-60. DOI: 10.1097/RTI.0000000000000541.

Published

2025-11-19

How to Cite

1.
Ferreira-Moreno VG, Álvarez-Herrera T, Camacho-Sosa K. Evaluation of the initial chest X-ray in the management of adult patients with COVID-19. Rev Méd Electrón [Internet]. 2025 Nov. 19 [cited 2026 Feb. 13];47:e6603. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/6603

Issue

Section

Research article