Collagen biostimulators, an effective therapy in skin aging
Keywords:
collagen biostimulators; facial rejuvenation; calcium hydroxyapatite; poly-l-lactic acidAbstract
Introduction: Once the adolescence is over, the skin becomes the organ that expresses the effects of time. In it the chronological advance is manifested through the appearance of the first expression lines, and the progressive decrease of firmness and elasticity. Collagen biostimulators—substances used in the field of esthetic medicine—promote skin rejuvenation by stimulating fibroblasts. The growing interest of the medical community and patients in these procedures has driven the development of products that offer excellent esthetic results and high acceptance.
Objective: To systematize relevant aspects of the use of collagen biostimulators.
Methods: The Virtual Library of Infomed, PubMed, and Google Scholar were used for research. Basic concepts of the subject were examined, including classifications, indications, procedures, and esthetic outcomes.
Results: Forty-seven articles were consulted; abstracts were examined in thirty-one of them, and the full text was analyzed in sixteen during the initial review. Twenty-two scientific documents were excluded because they did not meet the search criteria. Twenty-five articles were included that analyze the use of biostimulators in cosmetic dermatology, with more frequently used substances, application techniques, desired effects, and common adverse events.
Conclusions: The use of collagen biostimulators is a promising area of research to counteract photoaging effects; it produces satisfactory cosmetic changes for the patient.
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1. Vera-Ramírez V, Morales-Sánchez MA, Santa-Cruz FJ, et al. Escalas clínicas para evaluar el envejecimiento cutáneo: una revisión de la literatura. Rev Cent Dermatol Pascua. 2021;30(2):68-75. DOI: 10.35366/101176.
2. Cunha-Bernardo AF, Dos Santos K, Perreiras-Da Silva D. Pele: alterações anatômicas e fisiológicas do nascimento á maturidade. Rev Saúde Foco [Internet]. 2019 [citado 24/05/2025];11:1221-33. Disponible en: http://portal.unisepe.com.br/unifia/wp-content/uploads/sites/10001/2019/11/PELE-ALTERA%C3%87%C3%95ES-ANAT%C3%94MICAS-E-FISIOL%C3%93GICAS-DO-NASCIMENTO-%C3%80-MATURIDADE.pdf
3. Bartoletti E, Favaroni A, Cavalieri L, et al. Optimized calcium hydroxilpatite formulation and ITS injection technique for hand rejuvenation: A retrospective study. Dermatol Pract Concept. 2024;14(4):e2024283. DOI: 10.5826/dpc.1404a283.
4. Darias-Domínguez C, Ramírez-Fernández M, Soler-Cárdenas SF. Respuesta terapéutica de la crioterapia con nitrógeno líquido en el carcinoma basocelular. Rev Méd Electrón [Internet]. 2025 [citado 16/06/2025];47. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S1684-18242025000100052&lng=es&nrm=iso
5. Palmieri A, Avantaggiato A, Cura F, et al. Effect of biostimulation on oral fibroblast: a pilot study. J Biol Regul Homeost Agents [Internet]. 2017 [citado 24/05/2025];31(4 Supl 2):139-45. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29202574/
6. Fitzgerald R, Vleggaar D. Facial volume restoration of the aging face with poly-l-lactic acid. Dermatol Ther. 2011;24(1):2-27. DOI: 10.1111/j.1529-8019.2010.01375.x.
7. Da Silva-Beserra M, Siqueira-Larissa MS, Peixoto FB. Implicações do uso de bioestimuladores de colágeno no tratamento da face. Rev Eletr Acervo Saúde [Internet]. 2023 [citado 17/05/2025];23(1):e11560. Disponible en: https://acervomais.com.br/index.php/saude/article/view/11560
8. Marina-Ferreira A, Gentile P, Chiono V, et al. Collagen for bone tissue regeneration. Acta Biomater [Internet]. 2012 [citado 24/05/2025];8(9):3191-200. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1742706112002620?via%3Dihub
9. Miranda LHS. Ácido poli-l-lático e hidroxiapatita de cálcio: melhores indicações. En: Lyon S, Silva RC. Dermatologia estética: medicina e cirurgia estética. Rio de Janeiro: Medbook; 2015. p. 267-80.
10. Li K, Meng F, Li YR, et al. Application of nonsurgical modalities in improving facial aging. Int J Dent [Internet]. 2022 [citado 24/05/2025];2022:8332631. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35251183/
11. Ferreira-Pacheco de Oliveira CS, Da Silva-Almeida TJ, De Oliveira-Martins L, et al. Hidroxiapatita de cálcio: uma revisão quanto à eficacia, segurança e imaginologia quando usado como preenchedor e como bioestimulador. Res Soc Dev. 2021;10(14):21689. DOI: 10.33448/rsd-v10i14.21689.
12. Flores-Jiménez I, Martínez-Carpio PA, Alcolea López JM. Eficacia y seguridad de los tratamientos faciales con ácido poliláctico. Med Estét [Internet]. 2021 [citado 17/05/2025];67(2):16-24. Disponible en: https://www.seme.org/revista/articulos/eficacia-y-seguridad-de-los-tratamientos-faciales-con-acido-polilactico-revision-sistematica
13. Pedrosa J, Dias N, Santos R, et al. Uso de bioestimuladores de colágeno e seus efeitos no combate ao envelhecimento da pele. RECIMA [Internet]. 2021 [citado 17/05/2025]. Disponible en: https://repositorio.animaeducacao.com.br/items/6b4f2c2a-fedc-400d-ad29-0166dfe0ff7c
14. Neres-Seabra AM, Pereira-da Silva D. Bioestimulador de colágeno na harmonização facial: uma revisão de literatura. Res Soc Dev. 2022;14:1-7. DOI: 10.33448/rsd-v11i14.35713.
15. Pizzol-Camta C, Pereira-Barroso G. Análise comparativa teórica entre os biostimuladores de colágeno injetável [tesis en Internet]. Vila Velha: Instituto Federal de Espírito Santo; 2022 [citado 17/05/2025]. Disponible en: https://repositorio.ifes.edu.br/items/13430666-2f8b-4f84-843c-2b15edf6b9c0
16. Zago-Sá Fortes R, Cassol-Spanemberg J, Cherubini K, et al. Adverse Events and Satisfaction Outcomes with Calcium Hydroxylapatite and Polycaprolactone Fillers in Facial Aesthetics: A Systematic Review. Cosmetics. 2024;11(55):165. DOI: 10.3390/cosmetics11050165.
17. Loskot J, Jezbera D, Bezrouk A, et al. Raman Spectroscopy as a Novel Method for the Characterization of Polydioxanone Medical Stents Biodegradation. Materials (Basel). 2021;14(18):5462. DOI: 10.3390/ma14185462.
18. Loskot J, Jezbera D, Zmrhalová ZO, et al. A Complex In Vitro Degradation Study on Polydioxanone Biliary Stents during a Clinically Relevant Period with the Focus on Raman Spectroscopy Validation. Polymers (Basel). 2022;14(5):938. DOI: 10.3390/polym14050938.
19. Pedrero-Tomé R, Martínez-Álvarez JR, Tejero-García P. Polidioxanona inyectable: estudio de valoración de su eficacia y seguridad en medicina estética. Med Estét [Internet]. 2025 [citado 17/05/2025];83(2):21-8. Disponible en: https://www.seme.org/revista/articulos/polidioxanona-inyectable-estudio-de-valoracion-de-su-eficacia-y-seguridad-en-medicina-estetica
20. Wan J, Park Y, Park SY, et al. Volumizing and Cogged Threads for Nose Augmentation. J Cosmet Dermatol. 2024;23(12):4208-12. DOI: 10.1111/jocd.16542.
21. Kern JA, Kollipara R, Hoss E, et al. Serious Adverse Events with Injectable Fillers: Retrospective Analysis of 7659 Patient Outcomes. Dermatol Surg [Internet]. 2022 [citado 17/05/2025];48(5):551-5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35170541/
22. Itamura K, House AE, Pokress H, et al. Granulomatous deposition after calcium hydroxylapatite filler injection. J Cosmet Dermatol [Internet]. 2022 [citado 17/05/2025];21(12):7233-4. Disponible en: https://pubmed.ncbi.nlm.nih.gov/36102420/
23. Park JW, Choi SY, Kim KR, et al. A randomized, participant- and evaluator-blinded, matched-pair prospective study to compare the safety and efficacy between polycaprolactone-based fillers in the correction of nasolabial folds. Dermatol Ther [Internet]. 2022 [citado 17/05/2025];35(7):e15508. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35419911/
24. Go BC, Frost AS, Friedman O. Using injectable fillers for chin and jawline rejuvenation. World J Otorhinolaryngol Head Neck Surg [Internet]. 2023 [citado 17/05/2025];9(2):131-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/37383337/
25. Srinivasan A, Gupta A, Narayanamurthy V. A comprehensive of AI-based collagen valorization: Recent trends innovations in extraction, and applications. Green Anal Chem. 2025;12(100212). DOI: 10.1016/j.greeac.2025.100212.
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Copyright (c) 2026 Ovidio Fernando Zelaya-Rodríguez, Cristy Darias-Domínguez, Evelyn González-Betancourt
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