Malignant gliomas: molecular biology and oncogenic details

Authors

  • Enrique Marcos Sierra Benítez Hospital Universitario Comandante Faustino Pérez.Matanzas
  • Mairianny Quianella León Pérez Hospital Universitario Comandante Faustino Pérez.Matanzas
  • Lenier Laud Rodríguez Hospital Universitario Comandante Faustino Pérez.Matanzas
  • Alberto Lázaro Carrillo Comas Hospital Universitario Comandante Faustino Pérez.Matanzas
  • Letier Pérez Ortiz Hospital Universitario Comandante Faustino Pérez.Matanzas
  • Eglys Rodríguez Ramos Hospital Universitario Comandante Faustino Pérez.Matanzas

Keywords:

malignat gliomas, molecular biology, oncogenes

Abstract

The malignant gliomas biology is associated to the balance of the expression of the proteins controlling in a positive or negative way the cell cycle, vascular neo formation, proliferation, motility and the immune system recognition. The frequency of the genetic alterations that are present in GBM2 and GBM1 is different and also the age of the patients who present them. While GBM1 tend to appear at late ages, at around the age 60-70, GBM2 tend to appear at earlier ages, 40-50 years. There are molecular alterations at the level of the tumor suppressor genes, oncogenes, and DNA repair genes   in the genesis of the glioblastoma.

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Author Biography

Enrique Marcos Sierra Benítez, Hospital Universitario Comandante Faustino Pérez.Matanzas

Residente de neurocirugia

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Published

2018-07-18

How to Cite

1.
Sierra Benítez EM, León Pérez MQ, Laud Rodríguez L, Carrillo Comas AL, Pérez Ortiz L, Rodríguez Ramos E. Malignant gliomas: molecular biology and oncogenic details. Rev Méd Electrón [Internet]. 2018 Jul. 18 [cited 2025 Aug. 23];40(4):1100-11. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/2480

Issue

Vol. 40 No. 4 (2018)

Section

Review article

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