Recurrence prognostic factors in women with breast cancer. Hospital “Jose Ramon Lopez Tabrane”. Province of Matanzas. 2010-2015

Abstract

Introduction: breast neoplasm is the second cause of mortality in Cuban women. The knowledge of the recurrence prognostic factors is crucial for the treatment decision taking.
Objectives: to determine the recurrence prognostic factors due to breast cancer in this series.
Material and methods: a retrospective, analytic, observational, cohort study was carried out; participated 264 women diagnosed with breast cancer in the mastology consultation of the hospital “Jose Ramon Lopez Tabrane”, province of Matanzas, from January 1st 2010 to December 31st 2015. The Kaplan-Meier method was used to determine disease-free time, stratified according to the chosen variables, and a bi-variate analysis to estimate the relation between recurrence and each of these variables. Data were crossed in contingency tables and the relative risk (RR) and their confidence intervals (CI) of 95 % were calculated for each of them. The Chi squared test was used to find the significant statistic association. The independent effect of the chosen variables in the recurrence was verified by means of the Cox regression multivariate analysis.
Results: during the follow up, 64 patients had recurrence for an accumulated incidence of 24.2 %. The multivariate analysis by means of the Cox proportional risk model showed the worst prognosis in women with infiltration of the axillary lymph nodes (RR=5.65; CI: 2.21-14.44) and histological grade III (RR=3.44; CI 1.98-5.97).
Conclusions: the positive gangliar status and histological grade III were identified as recurrence risk factors. Knowing these factors directly affects survival and is decisive to individualize the treatment.