Neuleptic Malignant Syndrome in anesthetic management.
Keywords:
NEUROLEPTIC MALIGNANT SYNDROME, ANTIPSYCHOTIC AGENTS, ANESTHESIA AND ANALGESIA, HUMANAbstract
The Neuroleptic Malignant Syndrome (MNS) is a disturbance of rare apparition in patients treated with neuroleptic drugs. Its side effects are, very frequently, extensions of the pharmacologic action of the drugs on the Central Nervous System, the Cardiovascular System, the Autonomic Nervous System and other endocrine functions. Its extrapyramidal effects include five varieties of syndromes produced for the use of neuroleptic drugs. Three of them appear, almost always, simultaneously with the administration of the drugs, and the other two appear lately, after a prolonged treatment during months or years. Its incidence is of around 0,2 – 0,4 % of the patients treated with neuroleptics, and bigger in men, with a proportion of 2 : 145. The existence of a constant incidence pattern, higher in men than in women, is attributed to the clinicians´ tendency of using a more violent treatment in men because psychotic men are more violent than sick women. In 68 % of the cases, the symptoms appear during the first week of the neuroleptic treatment. 80 % of patients are under 40 years old with a minimum of 20 – 50 years and even when the young man is the typical patient, the Malignant Neuroleptic Syndrome can appear in children and old men taking neuroleptics by accident. We made this bibliographical revision to understand better the pharmacological action of these compounds, because although they are very frequently indicated in psychotic patients and, as we could see in the revised bibliography, the phenomena unchained by them are not very frequently, occasionally they could be very serious and potentially fatal.Downloads
Published
How to Cite
Issue
Section
License
All content published in this journal is Open Access, distributed under the terms of the CC BY-NC 4.0 License.
It allows:
- Copy and redistribute published material in any medium or format.
- Adapt the content.
This will be done under the following terms:
- Attribute the authors' credits and indicate whether changes were made, in which case it must be in a reasonable way.
- Non-commercial use.
- Recognize the journal where it is published.
The copyrights of each article are maintained, without restrictions.