Neuleptic Malignant Syndrome in anesthetic management.

Authors

  • María Isabel Liriano González HOSPITAL CLÍNICO-QUIRÚRGICO DOCENTE “JOSÉ RAMÓN LÓPEZ TABRANE”. MATANZAS.
  • Crescencio Aneiro Alfonso HOSPITAL CLÍNICO-QUIRÚRGICO DOCENTE “JOSÉ RAMÓN LÓPEZ TABRANE”. MATANZAS.
  • Pedro Olivera Mederos HOSPITAL CLÍNICO-QUIRÚRGICO DOCENTE “JOSÉ RAMÓN LÓPEZ TABRANE”. MATANZAS.
  • Ana Gloria Alfonso de León HOSPITAL CLÍNICO-QUIRÚRGICO DOCENTE “JOSÉ RAMÓN LÓPEZ TABRANE”. MATANZAS.

Keywords:

NEUROLEPTIC MALIGNANT SYNDROME, ANTIPSYCHOTIC AGENTS, ANESTHESIA AND ANALGESIA, HUMAN

Abstract

The Neuroleptic Malignant Syndrome (MNS) is a disturbance of rare apparition in patients treated with neuroleptic drugs. Its side effects are, very frequently, extensions of the pharmacologic action of the drugs on the Central Nervous System, the Cardiovascular System, the Autonomic Nervous System and other endocrine functions. Its extrapyramidal effects include five varieties of syndromes produced for the use of neuroleptic drugs. Three of them appear, almost always, simultaneously with the administration of the drugs, and the other two appear lately, after a prolonged treatment during months or years. Its incidence is of around 0,2 – 0,4 % of the patients treated with neuroleptics, and bigger in men, with a proportion of 2 : 145. The existence of a constant incidence pattern, higher in men than in women, is attributed to the clinicians´ tendency of using a more violent treatment in men because psychotic men are more violent than sick women. In 68 % of the cases, the symptoms appear during the first week of the neuroleptic treatment. 80 % of patients are under 40 years old with a minimum of 20 – 50 years and even when the young man is the typical patient, the Malignant Neuroleptic Syndrome can appear in children and old men taking neuroleptics by accident. We made this bibliographical revision to understand better the pharmacological action of these compounds, because although they are very frequently indicated in psychotic patients and, as we could see in the revised bibliography, the phenomena unchained by them are not very frequently, occasionally they could be very serious and potentially fatal.

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Published

2006-09-15

How to Cite

1.
Liriano González MI, Aneiro Alfonso C, Olivera Mederos P, Alfonso de León AG. Neuleptic Malignant Syndrome in anesthetic management. Rev Méd Electrón [Internet]. 2006 Sep. 15 [cited 2025 Jan. 9];28(5):443-51. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/324

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Section

Review article

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