Predictive and discriminating value of TNF Alfa in children with meningitis.

Authors

  • Amaury Noda Albelo HOSPITAL PEDIÁTRICO UNIVERSITARIO “ELISEO NOEL CAAMAÑO”. MATANZAS
  • Manuel Jesús Araña Rozaime HOSPITAL PEDIÁTRICO UNIVERSITARIO “ELISEO NOEL CAAMAÑO”. MATANZAS
  • Arturo Vidal Tallet HOSPITAL PEDIÁTRICO UNIVERSITARIO “ELISEO NOEL CAAMAÑO”. MATANZAS
  • Xiomara Casal Menéndez HOSPITAL PEDIÁTRICO UNIVERSITARIO “ELISEO NOEL CAAMAÑO”. MATANZAS
  • Boris L Rodríguez Ramos HOSPITAL PEDIÁTRICO UNIVERSITARIO “ELISEO NOEL CAAMAÑO”. MATANZAS

Keywords:

MENINGITIS, BACTERIAL, ASEPTIC, TUMOR NECROSIS FACTORS, TUMOR NECROSIS, ACTORS, ENZIME-LINKED IMMUNOSORBENT ASSAY, INTENSIVE CARE UNITS, PEDIATRIC, EMERGENCIES, LENGTH OF STAY, HUMANS, CHILD

Abstract

A descriptive, transversal, exploratory study was carried out in children with meningitis. The sample was chosen among the patients admitted in the Intensive Care Unit of the Pediatric Hospital “Juan Manuel Marquez” in Havana City and among those who attended the Emergency Unit of the Matanzas Pediatric Hospital in the period between March and August 2003. An ELISA test was used with the objective of quantifying TNF-? levels in cephalorachideal liquids and serum. In the case of TNF-?, there were not found concentration differences in cephalorachideal liquids and in serum in the patients included in this study, nor between the levels of this cytosine in every biological fluid in relation with the kind of meningitis. However, the analysis of the presence TNF-? levels higher than the detection limits of the used methods (50 pg/mL) showed that TNF-? in cephalorachideal liquids (6/6) was detected in all the patients suffering bacterial meningitis, while the presence of this pro-inflammatory cytosine in cephalorachideal liquids was found in only 50 % of the patients with aseptic meningitis (6/12). Nevertheless, this difference did not reach statistic significance.

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Published

2008-05-15

How to Cite

1.
Noda Albelo A, Araña Rozaime MJ, Vidal Tallet A, Casal Menéndez X, Rodríguez Ramos BL. Predictive and discriminating value of TNF Alfa in children with meningitis. Rev Méd Electrón [Internet]. 2008 May 15 [cited 2025 May 9];30(3):340-5. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/507

Issue

Vol. 30 No. 3 (2008)

Section

Research article

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