Study of morbidity and mortality of oral cancer at the Cárdenas Hospital. Experience of 20 years
Keywords:
oral cancer, epidemiology, morbidity, mortality, socio-demographic characteristicsAbstract
Introduction: The oral region is one of the ten most frequent locations of cancer incidence in the world. Its study in the environment is relevant to improve its prevention and cure, and to avoid aesthetic and functional affectations of the maxillofacial region.
Objective: To identify the distribution of morbidity and mortality per year of oral cancer in the territory of Cárdenas.
Methods: A 20-year retrospective descriptive study was carried out in patients with a histopathological diagnosis of oral cancer, treated at the General Teaching Hospital Julio M. Aristegui Villamil, in Cárdenas, in the period between January 2000 and December 2019.
Results: An increase in patients was observed when the morbidity rate rose from 5.8 x 100,000 inhabitants in 2000 to 16.3 in 2019, and mortality from 3.9 in 2001 to 8.9 in 2019. There was a higher incidence in the age group of 51-60 years, both in morbidity and mortality, male sex, white skin color, lower lip in morbidity, and mobile tongue and base mortality. The risk factors with the highest values were smoking and alcoholism.
Conclusions: oral cancer has a tendency to increase in the studied territory, in morbidity and mortality, as well as mortality at the national level. It is necessary to carry out health promotion activities as well as to detect it early through the research in the field visit.
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References
1. Laurencio-Rodríguez J, Oliveros-Noriega-Roldán S, Góngora-Rodríguez R. Caracterización clínico epidemiológica de pacientes con cáncer bucal y otras lesiones del complejo bucomaxilofacial. MEDISAN [Internet]. 2019 [citado 07/11/2020];23(5):837-46. Disponible en: https://medisan.sld.cu/index.php/san/article/view/2844
2. Gormley M, Dudding T, Sanderson E, et al. A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer. Nat Commun. 2020;11(1):6071. DOI: 10.1038/s41467-020-19822-6.
3. Miranda-Filho A, Bray F. Global patterns and trends in cancers of the lips, tongue and mouth. Oral Oncol [Internet]. 2020 [citado 02/02/2021];102:104551. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1368837519304610
4. Conway DI, Purkayastha M, Chestnutt IG. The changing epidemiology of oral cáncer. Definitions, trends y risk factors. Br Dent J [Internet]. 2018 [citado 02/02/2020];225(9):867-73. Disponible en: https://www.nature.com/articles/sj.bdj.2018.922
5. Álvarez Arias D, Munyo Estefan A, Borche G, et al. Cáncer de cabeza y cuello en Uruguay. Análisis de sobrevida en dos centros de referencia. Rev Med Urug [Internet]. 2018 [citado 14/11/2023];34(1):42-63. Disponible en: http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-03902018000100042
6. Lai K, Killingsworth M, Matthews S, et al. Differencesin survival outcome between oropharyngeal and oral cavity squamous cell carcinoma in relation to HPV Status. J Oral Pathol Med [Internet]. 2017 [citado 14/10/2020];46(8):574-82. Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/jop.12535
7. Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2022. CA: Cancer J Clin [Internet]. 2022 [citado 03/02/2023];72(1):7-33. Disponible en: https://acsjournals.onlinelibrary.wiley.com/doi/full/10.3322/caac.21708?utm_source=newsletter&utm_medium=email&utm_campaign=work-in-progress&utm_content=20230117
8. Chen SW, Zhang Q, Guo ZM, et al. Trends in clinical features and survival of oral cavity cancer: fifty years of experience with 3,362 consecutive cases from a single institution. Cancer Manag Res [Internet]. 2018 [citado 02/02/2020];10:4523-36. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190823/
9. Cintra-Castro Y, Llerena-Suárez J, Casañola-Rivero O, et al. Supervivencia de pacientes operados de neoplasias de cavidad oral estadios III-IV. Rev Cubana Otorrin Laringol Cabeza y Cuello [Internet]. 2020 [citado 02/11/2021];21(2):e158. Disponible en: https://www.google.com/search?client=firefox-b-d&q=Supervivencia+de+pacientes+operados+de+neoplasias+de+cavidad+oral+estadios+III-IV
10. Valentín González F, Rodríguez González GM, Conde Suárez HF, et al. Caracterización del cáncer bucal. Estudio de 15 años. Rev Méd Electrón [Internet]. 2017 [citado 02/10/2020];39(2):245-58. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1684-18242017000200010
11. Candia J, Fernández A, Somarriva C, et al. Mortalidad por cáncer oral en Chile, 2002-2012. Rev Méd Chile [Internet]. 2018 [citado 04/10/2020];146(4):487-93. Disponible en: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000400487
12. Acuña Pérez JL, Guillén Pérez DP, Rodríguez Herrera EV, et al. Mortalidad por cáncer bucal en Cuba en el periodo 2013-2017. Rev Caribeña de Ciencias Sociales [Internet]. 2019 [citado 40/10/2020]. Disponible en: https://www.eumed.net/rev/caribe/2019/04/cancer-bucal-cuba.html
13. Martín OR, Betancourt Valladares M, García Ranero AB, et al. Pronóstico de incidencia y mortalidad del cáncer bucal en la provincia Ciego de Ávila. Rev Cubana Estomatol [Internet]. 2017 [citado 04/10/2020];54(3). Disponible en: https://revestomatologia.sld.cu/index.php/est/article/view/1332/638
14. Diéguez-Pérez A, Correa-Rodríguez R, Fonseca-del-Rey S, et al. Caracterización del cáncer bucal en la Isla de la Juventud, 2007-2018. RMIJ [Internet]. 2019 [citado 05/05/2020];20(1). Disponible en: https://remij.sld.cu/index.php/remij/article/view/216/337
15. Gil Milá JD, Maestre Cabello JR, Martínez Gómez K. Caracterización de pacientes con cáncer oral y su relación con la invación en profundidad. Finlay [Internet]. 2021 [citado 20/02/2023];11(4):344-51. Disponible en: https://revfinlay.sld.cu/index.php/finlay/article/view/1070/0
16. Lins LS, Bezerra N, Freire AR, et al. Sociodemographic characteristics are related to the advanced clinical stage of oral cancer. Med Oral Patol Oral Cir Bucal [Internet]. 2019 [citado 23/03/2021];24(6):e759-63. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901145/pdf/medoral-24-e759.pdf
17. Herrera-Serna BY, Lara-Carrillo E, Toral-Rizo VH, et al. Relationship between the Human Development Index and its components with oral cáncer in Latin America. J Epidemiol Glob Health [Internet]. 2019 [citado 23/03/2021];9(4):223-32. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310789/pdf/JEGH-9-4-223.pdf
18. Pérez-Hernández A, Carmona-Fernández E, Velázquez-Martínez A, et al. Morbilidad del carcinoma epidermoide de lengua en Pinar del Río, 2000-2016. Rev Cien Méd Pinar Río [Internet]. 2016 [citado 04/05/2020];20(6):690-7. Disponible en: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/2832/pdf
19. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality wordwide for 36 cancers in 185 countries. Cancer J Clin [Internet]. 2018 [citado 23/03/2021];68(6):394-424. Disponible en: https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21492
20. Giraldi L, Leoncini E, Pastorino R, et al. Alcohol and cigarrette consuption predict mortality in patients with head and neck cáncer: a pooled analysis within the international Head and Neck Cancer Epidemiology (INHANCE) Consurtion. Ann Oncol [Internet]. 2017 [citado 06/11/2020];28(11):2843-51. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834132/pdf/mdx486.pdf
21. Oliver JR, Wu SP, Chang CM, et al. Survival of oral tongue squamous cell carcinoma in young adults. Head Neck [Internet]. 2019 [citado 02/02/2021];41(9):2960-8. Disponible en: https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.25772
22. Furtunato Bezerra NV, de França Leite KL, Davino de Medeiros MM, et al. Advanced stage tongue and mouth floor cancer is related to tobacco and alcohol abuse. J Public Health [Internet]. 2018 [citado 03/11/2020];26(2):151-6. Disponible en: https://link.springer.com/article/10.1007/s10389-017-0859-3
23. Campbell BR, Nitterville JL, Sinard RJ, et al. Early onset oral tongue cancer in the United States: a literature review. Oral Oncol [Internet]. 2018 [citado 03/11/2020];87:1-7. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1368837518303634
24. Khetan P, Boffetta P, Luce D, et al. Occupations and te risk of head and neck cáncer a pooled analysis of the International Head and Neck Epidemiology (INHANCE) Consortium. J Occup Environ Med [Internet]. 2019 [citado 03/03/2020];61(5):397-404. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613803/pdf/nihms-1521414.pdf
2. Gormley M, Dudding T, Sanderson E, et al. A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer. Nat Commun. 2020;11(1):6071. DOI: 10.1038/s41467-020-19822-6.
3. Miranda-Filho A, Bray F. Global patterns and trends in cancers of the lips, tongue and mouth. Oral Oncol [Internet]. 2020 [citado 02/02/2021];102:104551. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1368837519304610
4. Conway DI, Purkayastha M, Chestnutt IG. The changing epidemiology of oral cáncer. Definitions, trends y risk factors. Br Dent J [Internet]. 2018 [citado 02/02/2020];225(9):867-73. Disponible en: https://www.nature.com/articles/sj.bdj.2018.922
5. Álvarez Arias D, Munyo Estefan A, Borche G, et al. Cáncer de cabeza y cuello en Uruguay. Análisis de sobrevida en dos centros de referencia. Rev Med Urug [Internet]. 2018 [citado 14/11/2023];34(1):42-63. Disponible en: http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-03902018000100042
6. Lai K, Killingsworth M, Matthews S, et al. Differencesin survival outcome between oropharyngeal and oral cavity squamous cell carcinoma in relation to HPV Status. J Oral Pathol Med [Internet]. 2017 [citado 14/10/2020];46(8):574-82. Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/jop.12535
7. Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2022. CA: Cancer J Clin [Internet]. 2022 [citado 03/02/2023];72(1):7-33. Disponible en: https://acsjournals.onlinelibrary.wiley.com/doi/full/10.3322/caac.21708?utm_source=newsletter&utm_medium=email&utm_campaign=work-in-progress&utm_content=20230117
8. Chen SW, Zhang Q, Guo ZM, et al. Trends in clinical features and survival of oral cavity cancer: fifty years of experience with 3,362 consecutive cases from a single institution. Cancer Manag Res [Internet]. 2018 [citado 02/02/2020];10:4523-36. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190823/
9. Cintra-Castro Y, Llerena-Suárez J, Casañola-Rivero O, et al. Supervivencia de pacientes operados de neoplasias de cavidad oral estadios III-IV. Rev Cubana Otorrin Laringol Cabeza y Cuello [Internet]. 2020 [citado 02/11/2021];21(2):e158. Disponible en: https://www.google.com/search?client=firefox-b-d&q=Supervivencia+de+pacientes+operados+de+neoplasias+de+cavidad+oral+estadios+III-IV
10. Valentín González F, Rodríguez González GM, Conde Suárez HF, et al. Caracterización del cáncer bucal. Estudio de 15 años. Rev Méd Electrón [Internet]. 2017 [citado 02/10/2020];39(2):245-58. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1684-18242017000200010
11. Candia J, Fernández A, Somarriva C, et al. Mortalidad por cáncer oral en Chile, 2002-2012. Rev Méd Chile [Internet]. 2018 [citado 04/10/2020];146(4):487-93. Disponible en: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000400487
12. Acuña Pérez JL, Guillén Pérez DP, Rodríguez Herrera EV, et al. Mortalidad por cáncer bucal en Cuba en el periodo 2013-2017. Rev Caribeña de Ciencias Sociales [Internet]. 2019 [citado 40/10/2020]. Disponible en: https://www.eumed.net/rev/caribe/2019/04/cancer-bucal-cuba.html
13. Martín OR, Betancourt Valladares M, García Ranero AB, et al. Pronóstico de incidencia y mortalidad del cáncer bucal en la provincia Ciego de Ávila. Rev Cubana Estomatol [Internet]. 2017 [citado 04/10/2020];54(3). Disponible en: https://revestomatologia.sld.cu/index.php/est/article/view/1332/638
14. Diéguez-Pérez A, Correa-Rodríguez R, Fonseca-del-Rey S, et al. Caracterización del cáncer bucal en la Isla de la Juventud, 2007-2018. RMIJ [Internet]. 2019 [citado 05/05/2020];20(1). Disponible en: https://remij.sld.cu/index.php/remij/article/view/216/337
15. Gil Milá JD, Maestre Cabello JR, Martínez Gómez K. Caracterización de pacientes con cáncer oral y su relación con la invación en profundidad. Finlay [Internet]. 2021 [citado 20/02/2023];11(4):344-51. Disponible en: https://revfinlay.sld.cu/index.php/finlay/article/view/1070/0
16. Lins LS, Bezerra N, Freire AR, et al. Sociodemographic characteristics are related to the advanced clinical stage of oral cancer. Med Oral Patol Oral Cir Bucal [Internet]. 2019 [citado 23/03/2021];24(6):e759-63. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901145/pdf/medoral-24-e759.pdf
17. Herrera-Serna BY, Lara-Carrillo E, Toral-Rizo VH, et al. Relationship between the Human Development Index and its components with oral cáncer in Latin America. J Epidemiol Glob Health [Internet]. 2019 [citado 23/03/2021];9(4):223-32. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310789/pdf/JEGH-9-4-223.pdf
18. Pérez-Hernández A, Carmona-Fernández E, Velázquez-Martínez A, et al. Morbilidad del carcinoma epidermoide de lengua en Pinar del Río, 2000-2016. Rev Cien Méd Pinar Río [Internet]. 2016 [citado 04/05/2020];20(6):690-7. Disponible en: https://revcmpinar.sld.cu/index.php/publicaciones/article/view/2832/pdf
19. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality wordwide for 36 cancers in 185 countries. Cancer J Clin [Internet]. 2018 [citado 23/03/2021];68(6):394-424. Disponible en: https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21492
20. Giraldi L, Leoncini E, Pastorino R, et al. Alcohol and cigarrette consuption predict mortality in patients with head and neck cáncer: a pooled analysis within the international Head and Neck Cancer Epidemiology (INHANCE) Consurtion. Ann Oncol [Internet]. 2017 [citado 06/11/2020];28(11):2843-51. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834132/pdf/mdx486.pdf
21. Oliver JR, Wu SP, Chang CM, et al. Survival of oral tongue squamous cell carcinoma in young adults. Head Neck [Internet]. 2019 [citado 02/02/2021];41(9):2960-8. Disponible en: https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.25772
22. Furtunato Bezerra NV, de França Leite KL, Davino de Medeiros MM, et al. Advanced stage tongue and mouth floor cancer is related to tobacco and alcohol abuse. J Public Health [Internet]. 2018 [citado 03/11/2020];26(2):151-6. Disponible en: https://link.springer.com/article/10.1007/s10389-017-0859-3
23. Campbell BR, Nitterville JL, Sinard RJ, et al. Early onset oral tongue cancer in the United States: a literature review. Oral Oncol [Internet]. 2018 [citado 03/11/2020];87:1-7. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1368837518303634
24. Khetan P, Boffetta P, Luce D, et al. Occupations and te risk of head and neck cáncer a pooled analysis of the International Head and Neck Epidemiology (INHANCE) Consortium. J Occup Environ Med [Internet]. 2019 [citado 03/03/2020];61(5):397-404. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613803/pdf/nihms-1521414.pdf
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2024-12-04
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Valentín-González F, Rodríguez-González GM, Conde-Suárez HF. Study of morbidity and mortality of oral cancer at the Cárdenas Hospital. Experience of 20 years. Rev Méd Electrón [Internet]. 2024 Dec. 4 [cited 2026 Feb. 13];46:e5637. Available from: https://revmedicaelectronica.sld.cu/index.php/rme/article/view/5637
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